Domain boundaries of a largely non-redundant set of proteins for which structures have been submitted in the Brookhaven Protein Data Bank (Bernstein F.C. et al. & Tasumi, M., J. Mol. Biol. 112, 535-542 (1977)). The non-homologous dataserver at EMBL (by Hobohm, U., Scharf, M., Schneider, R. & Sander, C., Protein Science , 1, 409-417 (1992)) has been used as a guideline to obtain this dataset.
Domains have been identified based on the clustering of secondary structures. For details of the method you may also see the papers
( An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins by Sowdhamini, R. and Blundell, T.L. Protein Science , 4 , 506-520 (1995).
A database of globular protein structural domains : Clustering of representative family members into similar folds by Sowdhamini, R., Rufino, S.D. & Blundell, T.L. Folding and Design (in press). This algorithm has presently been applied to 436 protein chains. This table will be periodically updated (currently 14th Feb. 1996).
Table 1 : LIST OF PROTEIN DOMAINS USED FOR THE ANALYSIS. _______________________________________________________________________________________________________________________________________________________ PDB Ch. No. of D Domain boundaries Helix content Protein name Helix content code domains f for domains for full chain _______________________________________________________________________________________________________________________________________________________ 119l 2 1.32657 85 -155; 1.00 a Lysozyme (Bacteriophage T4) 3 - 80; 0.75 a 153l 2m 1.10290 18 - 74;169 -182; 1.00 a Lysozyme (Goose) 0.96 a 90 -149; 0.90 a 1aaj 2m 1.06212 3 - 4; 34 - 38; 56 - 68; 86 -105; 0.00 b Amicyanin 0.00 b 11 - 30; 42 - 47; 76 - 82; 0.00 b 1aak 2c 1.29120 8 -114; 0.46 ab Ubiquitin Conjugating Enzyme (124 -147;) 1abr B 2 1.59486 145 -265; 0.00 b Abrin-a 15 -138; 0.00 b 1add 2m 1.13004 11 - 17; 58 - 61; 95 -102;147 -350; 0.67 ab Adenosine Deaminase 0.76 a,ab 24 - 50; 69 - 92;126 -144; 1.00 a 1ads 2m 1.08695 3 -209;244 -273; 0.70 ab Aldose Reductase 0.74 ab 231 -240;282 -289; 1.00 a 1aep 1 1.00 a Apolipophorin III 1afp 1 0.00 b Antifungal Protein 1agx 2 1.52753 3 -191; 0.53 ab Glutaminase-asparaginase 218 -328; 0.68 ab 1alk A 2 1.12236 30 - 50; 80 -258;299 -323;335 -367;417 -446; 0.62 ab Alkaline Phosphatase 55 - 65;268 -288;325 -331;375 -402; 0.51 ab 1amp 1 0.67 ab Aminopeptidase 1amy 2c 1.12078 3 - 88;154 -402; 0.63 ab Alpha-1,4 Glycan-4-glucanohydrolase (97 -106;) 1aor A 4 1.29249 7 -204;520 -541;593 -599; 0.55 ab Aldehyde Ferredoxin Oxidoreductase 344 -491;545 -583; 0.96 a 232 -340; 0.75 ab 214 -230;503 -514; 1.00 a 1aoz A 3 1.35386 149 -155;345 -545; 0.28 ab Ascorbate Oxidase 135 -144;169 -327; 0.10 b 3 -122; 0.00 b 1apl C 1 1.00 a Mat Alpha2 Homeodomain 1apm E 3c+ 1.37148 43 -121;162 -163;189 -190; 0.31 ab c-AMP-dependent Protein Kinase 128 -159;172 -182;218 -233;263 -307; 0.91 a (207-210; 243-252;) 1apv E 3 1.44151 192 -303; 0.18 b Acid Proteinase 17 -144; 0.23 ab ,b 4 - 10;152 -183;306 -321; 0.00 b 1arb 2 1.10574 8 - 9;130 -262; 0.19 b Achromobacter Protease I 25 -119; 0.12 b 1ars 2+ 1.27450 51 -159;170 -310; 0.70 ab Aspartate Aminotransferase 18 - 34;161 -168;313 -405; 0.82 a 1ash 2m 1.16251 1 - 10; 82 -144; 1.00 a Hemoglobin 1.00 a 20 - 77; 1.00 a 1asz A 3 1.60920 242 -269;303 -484;522 -537; 0.65 ab Aspartyl Trna Synthetase 75 -238; 0.34 ab 275 -298;489 -513; 0.82 a 1atn A 4 1.61198 136 -177;273 -329; 0.57 ab Deoxyribonuclease I 15 - 90; 0.43 ab 7 - 11;102 -135;337 -370; 0.67 ab 181 -261; 0.85 a 1atx 1 0.00 b ATX Ia 1aty 1 1.00 a F1fo Atp Synthase Subunit C 1aya A 2m 1.28353 13 - 55;100 -101; 0.32 ab Tyrosine Phosphatase 0.44 ab 57 - 83; 0.71 ab 1baa 2 1.36096 31 - 39;112 -159; 0.88 a Endochitinase 8 - 14; 51 - 67;168 -171;191 -226; 1.00 a 1bab B 2m 1.29983 20 - 74;101 -118; 1.00 a Hemoglobin 1.00 a 5 - 15;124 -142; 1.00 a 1bar A 1 0.00 b Acidic Fibroblast Growth Factor 1bbl - 1 1.00 a Dihydrolipoamide Succinyltransferase 1bbo - 1 0.83 a Human Enhancer-binding Protein 1bbp A 1 0.17 b Bilin Binding Protein 1bbt 1 1 0.18 b 1bbt 2 1 0.08 b 1bcf A 2m 1.25906 83 -144; 1.00 a Bacterioferritin 1.00 a 5 - 64; 1.00 a 1bct 1 1.00 a Bacteriorhodopsin 1bet 2m 1.17807 17 - 38; 53 -114; 0.00 b Beta-nerve Growth Factor 0.00 b 41 - 50; 0.00 b 1bge B 2m 1.07854 12 - 40; 72 -124; 1.00 a Granulocyte Colony-stimulating Factor 1.00 a 49 - 55;144 -169; 1.00 a 1bmd A 2 1.26825 4 -153;242 -298; 0.61 ab Malate Dehydrogenase 156 -237;306 -328; 0.83 a 1bpb 3 1.53733 150 -273; 0.56 ab Dna Polymerase Beta 276 -321; 0.80 ab 94 -141; 1.00 a 1bsa A 1 0.44 ab Barnase 1bw4 1 0.32 ab Barwin, Basic Barley Seed Protein 1c5a 1 1.00 a Des-arg==74==-complement C5a 1cau A 3m 1.45221 56 - 93;107 -114;137 -140;157 -164; 0.00 b Canavalin 0.15 bb 97 -104 ;116 -133 ;145 -150 ;174 -176 ; 0.00 b 192 -207 ; 1.00 a 1cau B 2c 1.19232 258 -378;418 -420; 0.08 b Canavalin (392 -411;) 1cbn - 1 0.80 a Crambin 1ccf 2m 1.96045 76 - 84; 0.00 b Coagulation Factor X 0.00 b 60 - 71; 0.00 b 1ccr 2m 1.32376 58 - 82; 1.00 a Cytochrome c 1.00 a 11 - 21; 96 -109; 1.00 a 1cde 2+ 1.18110 2 -108; 0.59 ab Phosphoribosylglycinamide Formyltransferase 131 -202; 0.48 ab 1cdg 4* 17 - 406; 0.69 ab Cyclodextrin Glycosyltransferase 408 - 493; 0.00 b 500 - 581; 0.00 b 586 - 683; 0.00 b 1cdt A 2m 1.08645 20 - 54; 0.00 b Cardiotoxin V4II 0.00 b 2 - 13; 0.00 b 1cel A 3 1.34787 13 - 34; 78 -147;212 -228;274 -312;359 -425; 0.12 b 1,4-beta-d-glucan Cellobiohydrolase I 2 - 3; 41 - 73;182 -209;236 -239; 0.20 b 316 -356; 0.80 b 1cew I 1 0.30 ab Cystatin 1cfb 2 1.88515 721 -809; 0.00 b Drosophila Neuroglian 619 -708; 0.00 b 1chl 1 0.57 ab Chlorotoxin 1chm A 3 1.48344 6 -156; 0.66 ab Creatine Amidinohydrolase 219 -251;261 -311;360 -374;396 -401; 0.56 ab 161 -209;253 -258;329 -357;377 -388; 0.66 ab 1chr A 3+ 1.40620 135 -295; 0.69 ab Chloromuconate Cycloisomerase 0.75 ab 8 -116;360 -365; 0.89 a 120 -133;303 -347; 0.61 ab 1cid 2 1.31194 4 -110; 0.00 b Cd4 116 -176; 0.00 b 1cks A 1 0.60 ab Cyclin-dependent Kinase 1cmb A 1 0.91 a Met Apo-repressor 1cob A 1 0.00 b Superoxide Dismutase 1col A 2m 1.07425 76 -164; 1.00 a Colicin A 1.00 a 8 - 67;169 -198; 1.00 a 1cpc A 2c 1.11350 48 -172; 1.00 a C-phycocyanin (4-46;) 1cpt 4 1.50628 9 - 91;318 -345; 0.65 ab Cytochrome P450 150 -156;287 -295;398 -427; 0.39 ab 130 -145;161 -185;254 -285;300 -311;380 -394; 1.00 a 109 -126;208 -244; 1.00 a 1cpy 3 1.36779 46 - 50; 89 - 91;140 -175;317 -415; 0.56 ab Carboxypeptidase 18 - 35; 59 - 79;103 -129;271 -287; 0.61 ab 181 -251;300 -307; 1.00 a 1crl 4 1.34743 136 -144;210 -220;236 -240;319 -338;416 -513; 0.69 ab Lipase (Triacylglycerol Hydrolase) 3 - 27; 99 -120;150 -154;177 -208;227 -232; 0.25 ab 73 - 90;159 -172;253 -291; 1.00 a 343 -414;519 -526; 1.00 a 1cse I 1 0.34 ab Subtilisin Carlsberg 1csk A 1 0.00 b C-src Kinase 1csp 1 0.00 b Major Cold Shock Protein 1ctm 2 1.46004 2 -154;235 -245; 0.20 b Cytochrome F 177 -221; 0.00 b 1ctn 3 1.66415 159 -192;267 -442;518 -555; 0.62 ab Chitinase A 30 -131;210 -262; 0.32 ab 444 -514; 0.21 ab ,b 1ctt 3 1.57723 32 - 33; 49 -160; 0.60 ab Cytidine Deaminase 190 -292; 0.57 ab 6 - 20; 35 - 44; 1.00 a 1cus 1 0.70 ab Cutinase 1d66 A 1 1.00 a Gal4 1ddt 3 1.97436 389 -534; 0.00 b Diphtheria Toxin 206 -376; 0.97 a 12 -182; 0.40 ab 1dec 2m 1.07675 27 - 38; 0.00 b Decorsin 0.00 b 15 - 22; 0.00 b 1dfn A 1 0.00 b Defensin HNP-3 1dge 3* 1.42128 62 -209;225 -323; 0.76 ab Dialkylglycine Decarboxylase 29 - 53;326 -432; 0.62 ab 212 -220; 0.00 a 1dhr 3m 1.05896 172 -238; 0.42 ab Dihydropteridine Reductase 0.61 ab 8 - 81;122 -131; 0.47 ab 96 -121;144 -160; 1.00 a 1dlc 3 1.60162 295 -296;503 -643; 0.00 b Delta-endotoxin Cryiiia 259 -275;302 -451;471 -495; 0.18 b 63 -253;277 -280; 1.00 a 1dmc 1 1.00 a Cd-6 Metallothionein-1 1dsb A 2 1.22563 9 - 60;129 -187; 0.71 ab Disulfide Bond Formation Protein 66 -127; 1.00 a 1dts 2 1.16583 2 -115; 0.68 ab Dethiobiotin Synthase 141 -203; 0.58 ab 1dyn A 2m 1.12180 62 -119; 0.41 ab Dynamin Pleckstrin Homology domain 0.22 ab ,b 12 - 58; 0.00 b 1eca 2m 1.22439 20 - 71; 94 -111; 1.00 a Hemoglobin 1.00 a 3 - 14; 77 - 87;118 -135; 1.00 a 1ede 2 1.15688 23 - 80; 99 -163;231 -307; 0.63 ab Haloalkane Dehalogenase 4 - 5; 90 - 91;172 -227; 0.90 a 1eft 3 1.62789 11 - 36; 66 -209; 0.68 ab Elongation Factor Tu 222 -305; 0.00 b 313 -403; 0.00 b 1enh 1 1.00 a Engrailed Homeodomain 1epa B 1 0.25 ab Epididymal Retinoic Acid-binding Prote 1erb 1 0.18 b Retinol Binding Protein 1erc 1 1.00 a Pheromone Er-1 1erd - 1 1.00 a Pheromone Er-2 1erg 2m 1.35378 25 - 64; 0.00 b Human Complement Regulatory Protein 0.00 b 3 - 17; 0.00 b 1eri A 2m 1.23561 21 -114;147 -170;221 -275; 0.62 ab Eco Ri Endonuclease 0.60 ab 118 -121;179 -191; 0.33 ab 1erp 1 1.00 a Pheromone Er-10 1etb 1 2m 1.29649 12 - 24; 54 - 55;104 -123; 0.00 b Transthyretin (Prealbumin) 0.11 b 29 - 48 ; 67 - 73 ; 91 - 97 ; 0.19 b 1fba A 3m 1.09702 9 - 32; 73 -107;130 -151;183 -190;227 -301; 0.57 ab Fructose-1,6-bisphosphate Aldolase 0.74 ab 36 - 63;307 -337; 1.00 a 112 -124;160 -179;198 -218; 0.87 a 1fc2 C 1 1.00 a Immunoglobulin Fc 1fc2 D 2 1.60618 347 -441; 0.09 b Immunoglobulin Fc 240 -336; 0.20 b 1fcd A 2 1.34815 4 - 40; 59 -108;256 -324; 0.48 ab Flavocytochrome C Sulfide Dehydrogenase 45 - 49;132 -252;333 -398; 0.53 ab 1fcd C 2 1.48010 87 -172; 1.00 a Flavocytochrome C Sulfide Dehydrogenase 4 - 74; 1.00 a 1fct - 1 1.00 a Immunoglobulin Fc 1fha 2m 1.04246 14 -136; 1.00 a Ferritin 1.00 a 138 -181; 1.00 a 1fia B 1 1.00 a Fis Protein 1fkb 1 0.16 b Fk506 Binding Protein 1fnc 2 1.36457 164 -313; 0.64 ab Ferredoxin 38 -151; 0.13 b 1fod 4 1 1.00 a Immunoglobulin Fc 1frp A 2 1.34048 13 - 48; 74 -198; 0.44 ab Fructose-1,6-bisphosphatase 209 -333; 0.73 ab 1fru B 2m 1.31283 36 - 45; 78 - 94; 0.00 b Fc (Igg) Receptor 0.00 b 6 - 30; 50 - 51; 62 - 70; 0.00 b 1fxi A 1 0.23 ab ,b Ferredoxin I 1fxr A 2m 1.02287 3 - 6; 44 - 62; 0.56 ab Ferredoxin I (4fe-4s) 0.52 ab 16 - 36; 0.45 ab 1gal 3 1.40309 4 - 63;133 -146;171 -173;228 -287;544 -581; 0.50 ab Glucose Oxidase 116 -124;151 -156;185 -213;330 -427;458 -506; 0.69 ab 80 - 94;294 -326;434 -451;512 -513; 0.38 ab 1gau A 1 0.56 ab Erythroid Transcription Factor 1gca 2 1.52568 112 -255;296 -298; 0.71 ab Glucose/Galactose-binding protein 3 -109;258 -292; 0.66 ab 1gdh A 2 1.64753 102 -284; 0.67 ab D-glycerate Dehydrogenase 4 - 95;293 -321; 0.66 ab 1ghs A 4m 1.46334 2 - 53; 85 - 93;123 -129;163 -166;227 -232;271 -273; 0.29 ab 1,3-beta-glucanase 0.67 ab 169 -202 ;244 -255 ; 0.86 a 133 -159 ;205 -220 ; 0.88 a 59 - 76 ;103 -117 ; 1.00 a 1gky 3 1.29146 4 - 31; 82 -121;164 -183; 0.66 ab Guanylate Kinase 34 - 81; 0.32 ab 125 -157; 1.00 a 1glc G 3 1.14671 5 -244;438 -450; 0.57 ab Glycerol Kinase 245 -306;405 -433;466 -470; 0.31 ab 310 -399;479 -493; 0.90 a 1gmf A 2m 1.17423 33 - 64; 98 -116; 0.74 ab Granulocyte-macrophage Colony-stimulat 0.85 a 13 - 28; 74 - 87; 1.00 a 1gof 3 1.30035 160 -529;578 -580; 0.03 b Galactose Oxidase 546 -575;588 -638; 0.00 b 7 -147; 0.00 b 1gox 2 1.08021 33 -155;213 -356; 0.71 ab Glycolate Oxidase 8 - 26;165 -205; 1.00 a 1gp1 A 1 0.57 ab Glutathione Peroxidase 1gph 1 2 1.40801 235 -442; 0.70 ab 2 -226; 0.39 ab 1gpr 2 1.08835 51 -115; 0.00 b Glucose Permease 21 - 47;129 -161; 0.13 b 1gpt 1 0.39 ab Gamma-1-h Thionin 1gtr A 5c 2.05790 341 -342;465-543; 0.00 b Glutaminyl-trna Synthetase 344 -460; 0.79 a,ab 10 - 98;211 -278;303 -313; 0.67 ab 103 -209; 0.00 b (293 -299;324-338;) 1har 2 1.71241 28 - 83;130 -146; 0.56 ab Hiv-1 Reverse Transcriptase 105 -110;156 -211; 0.68 ab 1hcd 4m 1.16850 75 -104; 0.00 b Hisactophilin 0.00 b 5 - 24;114 -116; 0.00 b 52 - 64; 0.00 b 35 - 46; 0.00 b 1hcg B 2m 1.89298 27 - 38; 0.00 b Blood Coagulation Factor Xa 0.00 b 11 - 22; 0.00 b 1hcn A 2m 2.04699 11 - 29; 59 - 85; 0.00 b Human Chorionic Gonadotropin 0.10 b 35 - 56; 0.33 ab 1hcn B 1 0.00 b Human Chorionic Gonadotropin 1hcr A 1 1.00 a Hin Recombinase 1hdc A 3m 1.18952 8 - 58; 83 - 86;132 -137;175 -182;214 -239; 0.46 ab 3-alpha, 20-beta-hydroxysteroid Dehydr 0.68 ab 101 -111;188 -193; 1.00 a 64 - 78;113 -129; 1.00 a 1hdg O 2 1.47010 2 -145;315 -327; 0.55 ab Holo-d-glyceraldehyde-3-phosphate Dehy 149 -311; 0.43 ab 1hex 4c 1.42190 99 -133;159 -249; 0.64 ab 3-isopropylmalate Dehydrogenase 2 - 96;258 -300; 0.67 ab 305 -344; 1.00 a (145 -152;) 1hfc 1 0.63 ab Fibroblast Collagenase 1hfi 1 0.00 b Factor H, 15th C-module Pair 1hgj A 2 1.65626 66 - 71;100 -259; 0.25 ab Hemagglutinin 24 - 60; 86 - 89;266 -317; 0.00 b 1hjr A 2m 1.14489 2 - 34; 60 - 67; 98 -151; 0.44 ab Holliday Junction Resolvase 0.62 ab 40 - 58; 77 - 92; 1.00 a 1hks 1 0.76 a,ab Heat Shock Transcription Factor 1hlb 3m 1.30202 34 - 64;111 -129; 1.00 a Hemoglobin 1.00 a 68 -106 ; 1.00 a 14 - 30 ;136 -150 ; 1.00 a 1hle A 2 1.30440 24 -193;291 -357; 0.58 ab Horse Leukocyte Elastase Inhibitor 204 -289; 0.21 ab ,b 1hle B 1 0.00 b Horse Leukocyte Elastase Inhibitor 1hmy 2 1.53590 13 -172;308 -323; 0.58 ab Hhai Dna (Cytosine-c5-)-methyltransfer 192 -302; 0.58 ab 1hne E 2 1.33087 30 -108;235 -242; 0.18 b Human Neutrophil Elastase 20 - 21;135 -230; 0.00 b 1hng A 2 1.99552 3 - 98; 0.00 b Cd2 (Rat) 105 -170; 0.00 b 1hoe 1 0.00 b Alpha-Amylase Inhibitor Hoe-467A 1hre 1 0.00 b Heregulin-alpha 1hrt I 1 0.00 b Alpha-thrombin 1hsl A 2 1.28655 7 - 89;194 -228; 0.69 ab Histidine-binding Protein 92 -181; 0.50 ab 1htm B 1 0.96 a Hemagglutinin Ectodomain 1htp 2 1.33308 8 - 27; 49 - 50; 74 - 79;101 -105; 0.00 b H-protein 29 - 42; 55 - 69; 82 - 92; 0.47 ab 1htr P 1 1.00 a Progastricsin 1huc B 2 1.18125 56 -167;247 -248; 0.88 a Cathepsin B 170 -234; 0.00 b 1hun A 1 0.48 ab Human Macrophage Inflammatory Protein 1huw 1 1.00 a Human Growth Hormone 1hvd 4 1.63625 88 -157;191 -200;232 -245; 1.00 a Annexin V 17 - 85;306 -315; 1.00 a 247 -303; 1.00 a 169 -184;203 -225; 1.00 a 1iae 3c 1.55953 14 - 98; 0.54 ab Astacin (2 - 3;134 - 135;184 - 198;) (113 - 115; 164 - 166;) 1iag 2 1.25802 6 -147; 0.62 ab Adamalysin II 158 -193; 0.67 ab 1ifc 1 0.17 b Intestinal Fatty Acid Binding Protein 1igp 1 0.34 ab Inorganic Pyrophosphatase 1ilr 1 2m 1.01122 22 - 33; 65 - 81;120 -143; 0.00 b 0.00 b 11 - 17; 46 - 60; 99 -113;146 -150; 0.00 b 1irk 3 1.59870 1084 -1148;1188 -1204;1236 -1274; 0.92 a Insulin Receptor 996 -1077; 0.25 ab 1163 -1183;1215 -1223; 0.79 a,ab 1isc A 3m 1.37555 87 -113;130 -153;178 -186; 0.71 ab Iron(Iii) Superoxide Dismutase 0.81 a 20 - 26;118 -124;159 -173; 0.73 ab 29 - 75; 1.00 a 1isu A 1 0.60 ab High-potential Iron-sulfur Protein 1ivd 2 1.06443 121 -313;407 -413; 0.00 b Influenza A Subtype N2 Neuraminidase 96 -102;353 -392;418 -449; 0.00 b 1kab 2m 1.10411 10 - 36; 72 - 94; 0.00 b Staphylococcal Nuclease 0.33 ab 39 - 40; 97 -134; 0.77 a,ab 1knb 1 0.00 b Adenovirus Type 5 Fiber Protein (Recep 1knt 1 0.36 ab Collagen Type Vi (Kunitz-type Domain C 1ktx 1 0.00 b Kaliotoxin (Ktx) (Nmr, 11 Structures) 1lba 1 0.61 ab Lysozyme Mutant With Ala 6 Replaced By 1ldm 2 1.37456 22 -160;247 -325; 0.65 ab M=4= Lactate Dehydrogenase Ternary Com 164 -242; 0.90 a 1len A 3m 1.59446 82 -151; 0.00 b Lentil lectin 0.00 b 18 - 46; 0.00 b 63 - 70;159 -178; 0.00 b 1lga A 2 1.26361 54 - 57;151 -273; 0.88 a Lignin Peroxidase 16 - 49; 70 -130;283 -284; 0.94 a 1lis 1 1.00 a Lysin 1lki 2m 1.24684 10 - 11; 76 -142; 0.93 a Leukemia Inhibitory Factor 0.96 a 22 - 59;155 -177; 1.00 a 1loe B 1 Legume lectin 1lpb A 2m 1.89698 48 - 50; 67 - 70; 84 - 89; 0.00 b Lipase 0.00 b 28 - 39; 57 - 58; 0.00 b 1lpb B 2 1.41935 2 -327; 0.64 ab Lipase 338 -448; 0.00 b 1lpe 1 1.00 a Apolipoprotein-E3 1lts A 2m 1.25757 5 - 22; 66 - 88;119 -141; 0.39 ab Heat-labile Enterotoxin (Lt) 0.45 ab 41 - 63; 94 -116;158 -161; 0.54 ab 1lts C 1 1.00 a Heat-labile Enterotoxin (Lt) 1lts D 2 1.20510 26 - 77; 0.55 ab Heat-labile Enterotoxin (Lt) 5 - 22; 82 -100; 0.21 ab ,b 1lyp 1 1.00 a Cap18 (Residues 106 - 137) 1mat 3 1.19648 70 - 78;120 -164;206 -233; 0.61 ab Methionine Aminopeptidase 170 -203;236 -261; 0.00 b 8 - 57; 93 -114; 0.61 ab 1mdc 1 0.16 b Fatty Acid Binding Protein 1min A 3 1.58489 6 - 34;350 -467; 0.75 a,ab Nitrogenase Molybdenum-iron Protein 63 -205; 0.79 a,ab 222 -346; 0.77 a,ab 1mmo B 1 1.00 a Methane Monooxygenase Hydrolase 1mmo G 2m 1.39509 10 - 79; 1.00 a Methane Monooxygenase Hydrolase 1.00 a 87 -143; 1.00 a 1mrg 2 1.30245 2 - 24; 47 -172; 0.68 ab Alpha-momorcharin 27 - 37;183 -235; 0.53 ab 1mrt 1 Cd-7 Metallothionein-2 1msf C 2 1.64219 152 -185; 1.00 a C-myb Dnab inding Domain 100 -133; 1.00 a 1mup 2m 1.07213 25 - 36; 84 -154; 0.28 ab Major Urinary Protein 0.18 b 21 - 22; 45 - 77; 0.00 b 1myl B 1 1.00 a Arc Repressor 21 - 22; 45 - 77; 0.00 b 1myp C 4 1.64602 304 -331;435 -508; 1.00 a Myeloperoxidase 342 -381;533 -562; 0.62 ab 174 -293;522 -528; 1.00 a 128 -144;417 -428; 0.75 a 1nar 2m 1.08866 4 - 56; 79 -115;126 -288; 0.60 ab Narbonin 0.62 ab 60 - 74;117 -122; 0.78 a,ab 1nba A 2m 1.11546 45 - 50; 68 - 84;166 -233; 0.69 ab N-carbamoylsarcosine Amidohydrolase 0.62 ab 54 - 57; 89 -144; 0.27 ab 1nhk L 2c 1.11837 3 - 40; 72 -132; 0.59 ab Nucleoside Diphosphate Kinase (44 - 67;) 1nip B 2m 1.07038 3 -211;235 -249; 0.73 ab Nitrogenase Iron Protein 0.75 ab 216 -230; 1.00 a 1oct C 2 1.76768 6 - 74; 1.00 a Oct-1 (Pou Domain) 110 -159; 1.00 a 1ofv 2m+ 1.05570 3 - 53; 82 -166; 0.55 ab Flavodoxin 0.55 ab 56 - 69; 0.60 ab 1olb A 3 1.50353 48 -175;424 -475; 0.67 ab Oligo-peptide Binding Protein 264 -417;479 -490; 0.54 ab 14 - 43;191 -259;495 -514; 0.49 ab 1oma 1 0.00 b Omega-aga-IVB 1omp 2 1.27473 7 -111;167 -182;258 -329; 0.62 ab D-maltodextrin-binding Protein 114 -163;186 -245;336 -368; 0.81 a 1ovb 1 0.52 ab Ovotransferrin 1oxy 4 1.46657 383 -399;442 -465;484 -503;552 -566;617 -627; 0.11 b Hemocyanin Subunit II 3 -126;241 -248;517 -520; 0.94 a 161 -217;405 -438;510 -511;538 -539;580 -583; 0.63 ab 266 -375; 0.91 a 1oyb 2m 1.16912 20 -116;163 -191;217 -393; 0.71 ab Old Yellow Enzyme 0.72 ab 124 -160;197 -202; 0.79 a,ab 1paa 1 1.00 a Yeast Transcription Factor Adr1 1pbe 2 1.34712 47 - 99;175 -274;328 -386; 0.54 ab P-hydroxybenzoate Hydroxylase 5 - 40;102 -167;277 -318; 0.59 ab 1pbp 2 1.04766 69 -228;285 -295; Title 0.62 ab 3 - 67;253 -283;298 -314; 0.68 ab 1pcr H 1 0.45 ab Photosynthetic Reaction Center 1pcr L 4m 1.52261 116 -162;225 -250; 1.00 a Photosynthetic Reaction Center 0.96 a 24 -111; 0.90 a 259 -273; 1.00 a 171 -220; 1.00 a 1pda 3 1.635 5 - 98;201 -216; 0.55 ab Phorphobilinogen deaminase 106- 186; 0.60 ab 222- 304; 0.59 ab 1pdc 1 0.00 b Seminal Fluid Protein Pdc-109 1pdg B 3m 1.76428 17 - 62; 97 - 99; 0.00 b Platelet-derived Growth Factor 0.00 b 65 - 74; 85 - 94; 0.00 b 77 - 82; 0.00 b 1pet A 1 1.00 a Tumor Antigen P53 1pfi A 1 1.00 a Major Coat Protein Of Pf1 Virus 1pfk A 2 1.66217 3 -123;258 -302; 0.65 ab Phosphofructokinase 139 -246;309 -318; 0.77 a,ab 1pgb 1 0.37 ab Protein G (B1 Igg-binding Domain) 1pho 1 0.02 b Phosphoporin 1php 3 1.49183 15 -167;386 -389; 0.66 ab 3-phosphoglycerate Kinase (Pgk) 169 -217;243 -261;297 -380; 0.78 a,ab 221 -228;265 -295; 0.35 ab 1pii 2 1.42828 4 -211;229 -237; 0.65 ab N-(5'phosphoribosyl)anthranilate Isomerase 217 -223;242 -445; 0.64 ab 1pk4 2m 2.13793 1 - 2; 78 - 79; 0.00 b Plasminogen Kringle 4 0.00 b 62 - 74; 0.00 b 1pkn 3 1.51134 45 -112;222 -387; 0.74 ab Pyruvate Kinase 17 - 30;390 -528; 0.76 a,ab 138 -209; 0.00 b 1plq 2 1.38791 135 -250; 0.25 ab Proliferating Cell Nuclear Antigen 2 -117; 0.25 ab ,b 1pmy 2m 1.11493 2 - 92; 0.00 b Pseudoazurin (Cupredoxin) 0.28 ab 99 -120; 1.00 a 1pnt 1 0.74 ab Tyrosine Phosphatase 1poa 1 0.86 a Phospholipase A2 1poc 2 1.23579 40 - 59; 95 -129; 0.00 b Phospholipase A2 25 - 35; 61 - 89; 1.00 a 1pox A 2 1.28202 10 -178;373 -543; 0.67 ab Pyruvate Oxidase 199 -364;564 -588; 0.78 a,ab 1ppb L 1 1.00 a Alpha-thrombin 1ppn 1 0.56 ab Papain 1ppt - 1 1.00 a Avian Pancreatic Polypeptide 1prc C 4 1.60197 102 -136;262 -309; 1.00 a Photosynthetic Reaction Center 8 - 34;244 -247; 0.78 a,ab 172 -239; 1.00 a 52 - 81; 1.00 a 1prs 2+ 1.37928 4 - 86;119 -122; 0.26 ab Development-specific Protein S 93 -113;131 -173; 0.00 b 1prt A 2 1.00697 6 - 11; 23 - 54; 97 -136;191 -227; 0.52 ab Pertussis Toxin 15 - 21; 57 - 92;141 -162; 0.51 ab 1prt B 2 1.50457 27 - 92; 0.39 ab Pertussis Toxin 100 -190; 0.23 ab ,b 1prt D 1 0.16 b Pertussis Toxin 1prt F 1 0.26 ab Pertussis Toxin 1psm 1 1.00 a Spam-h1 1psp A 2m 2.14904 6 - 47; 0.71 ab Pancreatic Spasmolytic Polypeptide 0.67 ab 75 - 96; 0.60 ab 1ptx 1 0.32 ab Scorpion Toxin Ii 1pxt B 3c 1.07878 36 - 72; 88 -158;228 -287; 0.48 ab Peroxisomal 3-ketoacyl-coa Thiolase 202 -220;300 -415; 0.66 ab (76 -80;288 -294;) 1pya B 3 1.22776 152 -202;236 -261; 0.00 b Pyruvoyl-dependent Histidine Decarboxy 99 -102;124 -134;278 -297; 1.00 a 108 -122;207 -231; 0.71 ab 1pyp 2m 1.29328 120 -229; 0.62 ab Inorganic Pyrophosphatase 0.53 ab 4 - 19; 0.00 b 1rbl M 1 0.52 ab Ribulose 1,5 Bisphosphate CarboxylaseO 1rcb 1 0.93 a Interleukin 4 1rec 2 1.31479 102 -194; 0.93 a Recoverin 10 - 94; 0.90 a 1ret 1 1.00 a Gamma Delta Resolvase 1rfb A 1 1.00 a Interferon Gamma 1rib A 2 1.12735 34 -149;207 -253;269 -318; 1.00 a Protein R2 Of Ribonucleotide Reductase 153 -205;259 -267; 0.82 a 1rmi 1 1.00 a Interferon-beta 1rop A 1 1.00 a Rop 1rpa 2 1.24557 2 -141;220 -340; 0.70 ab Prostatic Acid Phosphatase 143 -215; 1.00 a 1rsy 2 1.54351 179 -194;223 -246; 0.00 b Synaptotagmin I 144 -166;205 -212;256 -261; 0.00 b 1rtp 1 2m 1.15612 40 - 64; 79 -107; 0.90 a Alpha-parvalbumin 0.94 a 2 - 32; 66 - 70; 1.00 a 1rva A 2m 1.11854 3 - 17; 37 -241; 0.55 ab Eco Rv Endonuclease 0.53 ab 22 - 32; 0.00 b 1s01 1 0.64 ab Subtilisin BPN' 1sac A 1 0.08 b Serum Amyloid P Component 1sbp 2 1.28993 97 -217;279 -308; 0.72 ab Sulfate-binding Protein 2 - 94;222 -270; 0.72 ab 1scm A 1 1.00 a Myosin 1scm B 2 1.69265 88 -148; 0.85 a Myosin 14 - 77; 1.00 a 1scm C 2 1.72643 83 -149; 0.83 a Myosin 8 - 76; 0.90 a 1scu A 2 1.42113 9 -135; 0.58 ab Succinyl-coa Synthetase 144 -287; 0.64 ab 1scu B 3 1.90334 240 -387; 0.73 ab Succinyl-coa Synthetase 5 - 15;104 -231; 0.56 ab 22 -100; 0.54 ab 1scy 1 0.56 ab Scyllatoxin (Leiurotoxin I) 1ses A 3 1.28122 4 - 21;118 -123;186 -384; 0.43 ab Seryl-trna Synthetase 136 -182;386 -417; 0.92 a 27 - 98; 1.00 a 1smr A 3 1.38554 191 -306; 0.30 ab Renin 13 -142; 0.15 b 2 - 9;150 -183;309 -325; 0.00 b 1spf 1 0.00 a Pulmonary Surfactant-associated Polype 1srg A 1 0.00 b Streptavidin 1tab I 1 0.00 b Trypsin Complex With Bowman-Birk Inhib 1tad A 2 1.36656 28 - 53;181 -341; 0.62 ab Transducin-alpha 59 -172; 1.00 a 1tap 1 0.40 ab Factor Xa Inhibitor 1tca 2 1.20842 13 -131;179 -287; 0.71 ab Lipase (Triacylglycerol Hydrolase) 142 -169;309 -314; 0.82 a 1tfi 1 0.00 b Transcriptional Elongation Factor Sii 1tgs I 1 0.50 ab Trypsinogen 1thv 2m 1.19091 2 -126;180 -203; 0.00 b Thaumatin Isoform A 0.22 ab ,b 130 -176; 1.00 a 1tie 1 0.00 b Erythrina Trypsin Inhibitor 1tlk 1 0.00 b Telokin 1tml 2 1.22750 40 -256; 0.74 ab Endo-1,4-beta-d-glucanase 12 - 32;276 -284; 1.00 a 1tnr A 1 0.00 b Tumor Necrosis Factor Receptor P55 1tnr R 3 2.37854 19 - 72; 0.00 b Tumor Necrosis Factor Receptor P55 123 -152; 0.00 b 83 -116; 0.00 b 1tph 1 2m 1.09175 6 -127;160 -164;206 -244; 0.59 ab 0.70 ab 139 -151;178 -203; 1.00 a 1tpl A 4+ 1.58872 21 - 46;312 -455; 0.75 a,ab Tyrosine Phenol-lyase 92 -214;250 -286; 0.60 ab 58 - 88;296 -308; 1.00 a 218 -246; 1.00 a 1tpn 2m 1.42838 20 - 45; 0.00 b Tissue-type Plasminogen Activator 0.00 b 6 - 15; 0.00 b 1trb 2 1.55792 3 -116;245 -313; 0.48 ab Thioredoxin Reductase 122 -241; 0.45 ab 1trk A 4 1.62656 6 -300; 0.80 a Transketolase 356 -542;591 -596; 0.70 ab 547 -587;599 -667; 0.67 ab 302 -335; 1.00 a 1trz B 1 1.00 a Insulin (T3r3) 1tss A 2 1.31020 18 - 98;119 -124;181 -182; 0.00 b Toxic Shock Syndrome Toxin 1 4 - 14;102 -110;126 -167;186 -194; 0.47 ab 1tvs 1 1.00 a Transactivator Protein 1tys 1 0.53 ab Thymidylate Synthase 1ula 2 1.22058 116 -218;234 -278; 0.55 ab Purine Nucleoside Phosphorylase 8 -113;222 -230; 0.60 ab 1vaa A 2 1.49617 3 -179; 0.55 ab Mhc Class I H-2k==b== 186 -272; 0.00 b 1vil 2m 1.10373 46 -109; 0.59 ab Villin 0.45 ab 20 - 40;115 -117; 0.00 b 1vmo A 1 0.00 b Vitelline Membrane Outer Layer Protein 1was 1 1.00 a Bacterial Aspartate Receptor 1wsy A 2m 1.08418 2 - 24; 48 - 51; 78 -233; 0.69 ab Tryptophan Synthase 0.79 a,ab 30 - 42; 63 - 73;236 -264; 1.00 a 1wsy B 2 1.27986 59 - 77;207 -390; 0.59 ab Tryptophan Synthase 22 - 51; 88 -203; 0.82 a 1xnb 1 0.08 b Xylanase (Endo-1,4-beta-xylanase) 1ypt A 1 0.63 ab Protein-tyrosine Phosphatase 1ytb A 2 1.37170 66 -165; 0.37 ab Tatab ox Binding Protein 172 -236; 0.59 ab 1zaa C 2 1.41278 35 - 82; 0.71 ab Zif268 Immediate Early Gene 5 - 30; 0.75 ab 2abk 3 1.43547 3 - 16;139 -185; 1.00 a 29 - 54;108 -130; 1.00 a 61 - 98; 1.00 a 2ach B 1 0.00 b Alpha1 Antichymotrypsin 2ak3 A 2c 1.17790 7 -113;164 -211; 0.79 a,ab Adenylate Kinase Isoenzyme-3 (116 -137;) 2alp 2 1.07851 15B-120K;231 -242; 0.13 b Alpha-lytic Protease 135 -230; 0.00 b 2atc B 1 0.60 ab Aspartate Carbamoyltransferase 2ayh 1 0.04 b 1,3-1,4-beta-d-glucan 4 Glucanohydrola 2aza A 1 0.26 ab Azurin 2bbk H 3 1.41682 69 -203; 0.00 b Methylamine Dehydrogenase 219 -320; 0.09 b 33 - 64;322 -368; 0.00 b 2bbv A 2m 1.08002 91 -323; 0.08 b Black Beetle Virus Capsid Protein 0.22 ab ,b 61 - 71;334 -352; 0.92 a 2bds 1 0.00 b BDS-I 2bop A 1 0.44 ab Bovine Papillomavirus-1 E2 2bpa 1 2 1.32643 10 -161;235 -290;402 -423; 0.28 ab 192 -221;301 -383; 0.84 a 2bpa 2 1 0.00 b Bacteriophage Phix174 Capsid Proteins 2bpa 3 1 Bacteriophage Phix174 Capsid Proteins 2btf P 1 0.45 ab Beta-actin-profilin Complex 2cas 2c 1.06691 49 -399;455 -580; 0.13 b Canine Parvovirus Empty Capsid (415-430;) 2cba 1 0.18 b Carbonic Anhydrase II 2cbh 1 0.00 b C-terminal Domain Of Cellobiohydrolase 2ccy A 1 1.00 a Cytochrome c' 2cdv 2m 1.31200 9 - 20; 65 - 98; 0.79 a,ab Cytochrome c=3= 0.73 ab 30 - 41; 0.50 ab 2chs A 2m 1.08196 3 - 11; 42 - 49; 73 -108; 0.00 b Chorismate Mutase 0.42 ab 17 - 35; 60 - 64; 1.00 a 2cnd 2 1.29636 119 -269; 0.52 ab Nadh-dependent Nitrate Reductase 13 -116; 0.14 b 2cp4 4 1.54823 53 - 95;298 -327; 0.45 ab Cytochrome P450cam 38 - 42;147 -153;174 -185;235 -264;382 -405; 0.81 a 121 -142;157 -167;268 -291;360 -377; 1.00 a 108 -119;193 -232; 0.91 a 2cpl 1 0.29 ab Cyclophilin A 2crd 1 0.62 ab Charybdotoxin 2cro 1 1.00 a 434 Cro Protein 2ctc 1 0.70 ab Carboxypeptidase A 2cts 4 1.44416 57 -116;209 -234;328 -340;375 -384; 0.93 a Citrate Synthase - (CoA, Citrate) 122 -194;243 -269;393 -414; 1.00 a 277 -310;345 -363; 1.00 a 38 - 42;427 -434; 1.00 a 2dnj A 2 1.19628 2 - 11; 34 - 40; 64 -232;255 -258; 0.30 ab Deoxyribonuclease I 13 - 30; 46 - 55;235 -249; 1.00 a 2dri 2 1.48774 105 -234;266 -268; 0.70 ab D-ribose-binding Protein 3 -103;237 -263; 0.63 ab 2drp A 2m 1.95667 104 -133; 0.55 ab Tramtrack Protein 0.63 ab 141 -163; 0.73 ab 2ebn 2+ 1.16361 11 - 17; 41 -223;245 -249; 0.46 ab Endo-beta-n-acetylglucosaminidase F1 29 - 31;232 -241;262 -280; 0.79 a,ab 2ech 1 0.00 b Echistatin 2end 1 1.00 a Endonuclease V 2gda 1 0.83 a Glucocorticoid Receptor 2gdm 2m 1.15486 22 - 36;107 -122; 1.00 a Leghemoglobin (Oxy) 1.00 a 5 - 19; 58 - 81; 1.00 a 2glt 3 1.70479 3 -121;301 -313; 0.52 ab 208 -294; 0.41 ab 138 -199; 0.53 ab 2gst A 2 1.33638 2 - 82;191 -197; 0.61 ab Glutathione S-transferase 90 -114;130 -188; 1.00 a 2hbg 2 1.13809 24 - 71;103 -118; 1.00 a Hemoglobin 4 - 18; 76 - 89;124 -145; 1.00 a 2hhm A 2 1.10547 6 -141;190 -259; 0.57 ab Human Inositol Monophosphatase Dimer C 154 -185; 0.70 ab 2hip A 1 0.00 b High Potential Iron Sulfur Protein 2hmz A 1 1.00 a Hemerythrin 2hnq 2+ 1.26129 69 -214; 0.29 ab Protein-tyrosine Phosphatase 1b 6 - 26;220 -278; 1.00 a 2hnt E 1 0.50 ab Gamma-thrombin 2hpd A 4 1.40306 112 -158;251 -324;403 -450; 0.87 a Cytochrome P450 (Bm-3) 25 - 69;330 -367; 0.46 ab 94 -103;198 -238; 1.00 a 73 - 82;172 -189; 1.00 a 2hpe A 1 0.13 b Hiv-2 Protease 2hsp 2m 1.76276 41 - 55; 0.00 b Phospholipase C-gamma (Sh3 Domain) 0.00 b 9 - 31; 0.00 b 2ihl 2 1.27144 43 - 98; 0.56 ab Lysozyme 5 - 36;109 -114; 1.00 a 2lgs A 3c 1.29888 104 -135;189 -455; 0.70 ab Glutamine Synthetase 2 - 92; 0.31 ab (137 - 152;459 - 465;) 2liv 2 1.56353 3 -116;259 -316; 0.72 ab Leu/Ile/Val-binding protein 124 -248;330 -342; 0.62 ab 2mad L 2c 1.41227 32 - 52; 76 -122; 0.00 b Methylamine Dehydrogenase (57 - 74;126 -129;) 2mev 1 1 0.14 b Mengo Encephalomyocarditis Virus Coat 2mge 2m 1.06857 4 - 77;101 -118; 1.00 a Myoglobin 1.00 a 83 - 95;125 -149; 1.00 a 2mnr 2 1.19044 22 - 29;123 -338; 0.69 ab Mandelate Racemase 6 - 16; 32 -118;351 -357; 0.66 ab 2mrb 1 Cd-7 Metallothionein-2a 2ms2 A 2m 1.18327 7 - 93; 0.00 b Ms2 Virus (Bacteriophage) 0.26 ab 98 -123; 1.00 a 2msb A 2 1.15422 112 -152;214 -220; 0.54 ab Mannose-binding Protein A 156 -208; 0.00 b 2mta C 1 1.00 a Methylamine Dehydrogenase 2ohx A 3 1.59449 175 -316; 0.67 ab Alcohol Dehydrogenase 35 - 91;149 -169;324 -373; 0.44 ab 7 - 28;130 -137; 0.00 b 2pcd A 2 1.19707 17 -109;126 -145;171 -188; 0.15 b Protocatechuate 3,4-dioxygenase 114 -122;149 -167; 0.69 ab 2pde 1 1.00 a Dihydrolipoamide Acetyltransferase 2pgd 3 1.56958 5 -175; 0.68 ab 6-phosphogluconate Dehydrogenase 178 -291;315 -348;392 -433; 1.00 a 354 -381; 1.00 a 2phy 1 0.46 ab Photoactive Yellow Protein 2pia 3 1.91805 113 -223; 0.53 ab Phthalate Dioxygenase Reductase 238 -319; 0.21 ab ,b 9 - 98; 0.15 b 2pmg A 4 1.67964 4 -188; 0.52 ab Phosphoglucomutase 305 -382;408 -419;540 -549; 0.66 ab 192 -303;390 -403; 0.76 a,ab 421 -537; 0.34 ab 2por 1 0.09 b Porin 2reb 3 1.59416 39 - 40; 56 - 94;115 -144;166 -218; 0.66 ab Rec A Protein 270 -327; 0.76 a,ab 45 - 50;101 -106;221 -268; 0.25 a,ab 2rn2 1 0.55 ab Ribonuclease H 2rsl B 1 0.69 ab Gamma Delta Resolvase 2rsp B 1 0.15 b Rous Sarcoma Virus Protease 2sas 2m 1.14916 4 -114;158 -170; 0.96 a Sarcoplasmic Calcium-binding Protein 0.96 a 124 -149; 1.00 a 2scp A 2 1.19726 25 - 59; 90 -159; 0.95 a Sarcoplasmic Calcium-binding Protein 2 - 23; 70 - 82; 0.86 a 2sil 1 0.07 b Sialidase (Neuraminidase) 2sn3 1 0.40 ab Scorpion Neurotoxin 2snv 2 1.31782 188 -263; 0.00 b Sindbis Virus Capsid Protein 115 -168; 0.00 b 2stv 2m 1.35497 43 - 46; 83 -135;170 -177; 0.21 ab ,b Satellite Tobacco Necrosis Virus 0.10 b 26 - 37; 64 - 77;142 -150;183 -193; 0.00 b 2tbv A 2 1.49997 274 -376; 0.00 b Tomato Bushy Stunt Virus 106 -264; 0.07 b 2tgi 2 1.49854 21 - 40; 83 -106; 0.14 b Transforming Growth Factor-beta 4 - 18; 43 - 80;109 -112; 0.53 ab 2tmd A 3 1.72570 13 -336; 0.66 ab Trimethylamine Dehydrogenase 350 -357;428 -431;489 -646; 0.48 ab 391 -418;442 -485;649 -693; 0.73 ab 2tmv P 2c 1.35202 20 - 50; 76 -134; 0.63 ab Intact Tobacco Mosaic Virus (10 - 18; 68 - 70;138 -148;) 2tpr A 3 1.62000 50 -114;161 -288; 0.66 ab Trypanothione Reductase 362 -477; 0.47 ab 2 - 34;119 -157;321 -348; 0.37 ab 2ts1 2 1.24196 2 -220; 0.77 a,ab Tyrosyl-transfer RNA Synthetase 248 -318; 1.00 a 2zta A 1 1.00 a GCN4 Leucine Zipper 3aah A 7 1.98217 26 - 27;392 -405;444 -502; 0.00 b Methanol Dehydrogenase 2 - 9;112 -193; 0.17 b 305 -363; 0.00 b 375 -378;407 -433;534 -552; 0.33 ab 41 - 47;512 -526;565 -570; 0.00 b 241 -289; 0.00 b 59 - 90; 0.00 b 3aah B 1 1.00 a Methanol Dehydrogenase 3bcl 2 1.18536 4 - 68;122 -127;244 -279;300 -357; 0.15 b Bacteriochlorophyll-a Protein 71 -117;136 -229;284 -290; 0.35 ab 3cd4 2 1.28261 108 -177; Cd4 0.00 b (N-terminal Fragment Consisting Of 2 -102; 0.00 b 3chy 1 0.73 ab CheY 3cla 2 1.23874 32 - 67; 90 -214; 0.51 ab Type III Chloramphenicol Acetyltransfe 8 - 27; 75 - 86; 0.43 ab 3cox 4 1.64646 11 - 40;232 -287;470 -472; 0.28 ab Cholesterol Oxidase 162 -204;324 -380;407 -424; 0.62 ab 96 -109;290 -303;388 -399;444 -445; 0.41 ab 128 -155;487 -504; 1.00 a 3dfr 2+ 1.24410 38 -105; 0.58 ab Dihydrofolate Reductase 2 - 32;112 -160; 0.20 ab ,b 3ebx 2m 1.15942 23 - 49; 0.00 b Erabutoxin b 0.00 b 2 - 15; 0.00 b 3egf 1 0.00 b Epidermal Growth Factor (Egf) 3gap A 2 1.33272 9 -134; 0.63 ab Catabolite Gene Activator Protein 139 -189; 1.00 a 3gly 2 1.23122 51 -237; 0.90 a Glucoamylase-471 (1,4-alpha-d-glucan G 2 - 19;247 -429; 0.90 a 3hhr C 2 1.67892 35 -125;163 -166; 0.10 b Human Growth Hormone 137 -160;174 -234; 0.00 b 3hsc 4 1.59087 38 -135; 0.52 ab 7 - 28;141 -182;368 -379; 0.53 ab 193 -225;315 -353; 0.38 ab 230 -312; 0.74 ab 3il8 1 0.47 ab Interleukin 8 3mdd A 3c 1.45014 92 -233; 0.37 ab Medium Chain Acyl-CoA Dehydrogenase 18 - 90;244 -278;292 -392; 1.00 a (282 -287;) 3mon A 1 0.00 b Monellin 3sdh A 2m 1.11478 3 - 8; 87 -111;129 -145; 1.00 a Hemoglobin I (Homodimer) 1.00 a 12 - 82;115 -124; 1.00 a 3sgb I 1 0.53 ab Proteinase B From Streptomyces Griseus 4blm A 2 1.30377 32 - 67;180 -195;230 -290; 0.44 ab Beta-Lactamase (Penicillinase) 72 -154;201 -212; 0.93 a 4cpa I 1 0.00 b Carboxypeptidase A=alpha= (Cox) 4enl 2 1.20405 129 -425; 0.72 ab Enolase (2-phospho-D-glycerate Hydrola 4 -125; 0.68 ab 4fxn 1 0.62 ab Flavodoxin (Semiquinone Form) 4gcr 2+ 1.42345 2 - 84; 0.00 b Gammab Crystallin 88 -158; 0.13 b 4gpb 3 1.45667 81 - 85;135 -159;191 -247;290 -481;813 -823; 0.63 ab Glycogen Phosphorylase B 167 -178;497 -805; 0.81 a 21 - 77; 95 -123; 1.00 a 4rhv 1 2 1.37313 67 -255; 0.14 b 18 - 57; 0.00 b 4rhv 2 1 0.09 b Rhinovirus 14 (HRV14) 4rhv 3 0* 43-222; 0.18 b Rhinovirus 14 (HRV14) 4rhv 4 1 1.00 a Rhinovirus 14 (HRV14) 4sbv A 3 1.24539 85 - 90;130 -186;223 -229; 0.16 b Southern Bean Mosaic Virus Coat Protein 98 -104;197 -219; 0.90 a 67 - 80;109 -121;237 -250; 0.00 b 4sgb I 1 0.00 b Serine Proteinase B 4tgf 2m 2.25260 38 - 46; 0.00 b Des-val==1==,Val==2==-transforming Gro 0.00 b 20 - 33; 0.00 b 4xia A 2c 1.15259 10 -337;379 -390; 0.82 a D-Xylose Isomerase (354 -372;) 5fd1 1 0.67 ab Ferredoxin 5p21 2m 1.02065 69 -164; 0.74 ab c-H-ras p21 Protein 0.56 ab 2 - 58; 0.26 ab 6fab L 2 1.90025 4 -106; 0.00 b Antigen-binding Fragment Of The Murine 114 -210; 0.15 b 7api B 1 0.00 b Modified Alpha=1=-Antitrypsin 7ccp 3 1.32040 36 - 39;179 -240; 0.63 ab Cytochrome C Peroxidase 16 - 32; 43 -118; 1.00 a 151 -172;242 -271; 1.00 a 7pti 1 0.36 ab Bovine Pancreatic Trypsin Inhibitor 7rsa 2 1.27920 4 - 12; 51 - 74;106 -123; 0.41 ab Ribonuclease A 25 - 47; 79 -104; 0.28 ab 7znf 1 0.69 ab Zinc-finger (Zfy-swap) 8abp 3+ 1.46153 135 -141;169 -253;287 -300; 0.52 ab L-Arabinose-binding Protein 3 -108;256 -283; 0.64 ab 110 -128;146 -162; 1.00 a 8acn 3 1.52287 18 - 98;121 -208;236 -314;517 -518; 0.64 ab Aconitase 552 -751; 0.53 ab 109 -119;217 -228;321 -495; 0.70 ab 8atc A 3 1.40255 135 -290; 0.66 ab Aspartate Carbamoyltransferase 43 -129; 0.58 ab 17 - 32;292 -304; 1.00 a 8cat A 2 1.32035 10 - 16; 77 -147;213 -237;259 -364; 0.38 ab Catalase 160 -198;246 -255;440 -499; 1.00 a 8fab B 2 1.78801 3 -119; 0.00 b Fab Fragment From Human Immunoglobulin 128 -218; 0.08 b 8rxn A 1 0.00 b Rubredoxin 8tln E 2 1.45014 4 -151; Thermolysin Complexed With Val-lys Dip 0.46 ab 159 -312; 0.89 a 9rnt 1 0.36 ab Ribonuclease T=1= Complex With Ca==2+= 9rub A 4+ 1.67664 143 -164;189 -191;227 -286;305 -392; 0.61 ab Ribulose-1,5-bisphosphate Carboxylase 14 -127;302 -303; 0.44 ab 173 -181;198 -218; 0.86 a 403 -439; 1.00 a 9wga A 2 1.51234 103 -160; 0.50 ab Wheat Germ Agglutinin (Isolectin 2) 17 - 74; 0.50 ab _______________________________________________________________________________________________________________________________________________________ Ch. : Chain identifier D : disjoint factor (for details see Sowdhamini & Blundell, 1995). f Helix content gives a measure of the secondary structural content. This is the ratio between the number of residues in helices to the number of residues in both helices and extended strands. a: refers to helix-rich domains (helix content more than 0.80) b: refers to strand-rich domains (helix content less than 0.20) ab: refers to domains composed of helices and strands (helix content with intermediate values) m The domains corresponding to one of the clusters is not structurally compact; clusters are merged and considered as single-domain fold. c One of the clusters marked within brackets corresponds to a domain less than 25 residues; this small cluster is ignored. * The domain boundaries suggested by DIAL was quite different from graphical inspection; hence user-defined boundaries are used. + The domain boundaries suggested by DIAL have been altered slightly for structure comparison by SEA. (a) Residues 11-31 have been included in the second domain of 1apm (E chain). (b) Residues 161-168 are considered part of the first domain of 1ars. (c) 1cde is considered as a single domain fold. (d) Residues 135 -295 (first domain) of 1chr (A chain) are considered part of the third domain. (e) Residues 3-120 and 141-166 of 1ofv are alone considered as a single domain fold. (f) Residues 119-122 of domain 1 of 1prs are considered part of the second domain. (g) The second (residues 92 to 214 and 250 to 286) and fourth domains (residues 218 to 246) in 1tpl (A chain) are considered part of the third domain. (h) 2ebn, 2hnq and 3dfr are considered as a single domain fold. (i) Residues 159-169 are also considered part of the second domain in 4gcr. (j) The third domain (residues 110-128 and 146-162) of 8abp is considered part of the first domain. (k) Domains 3 and 4 of 9rub (A chain) are considered part of the first domain.