Re: MINI-PROJECTS

P. Murray-Rust (mbglx@s-crim1.dl.ac.uk)
Sun, 22 Jan 1995 19:13:07 +0000 (GMT)

Lin raises an excellent point and one which is difficult! Proteins are
best described by their coordinates (usually in PDB form) and these can
be obtained from PDB at Brookhaven (which I hope most of you have managed
to access by now!). Unfortunately, not all authors deposit their
coordinates. Some journals require them to (Acta Crystallographica,
J.Mol.Biol. (I think), Structure (I think)) but others like Nature do not.
This means that some key structures do not have coordinates deposited.

The second point is that authors do not deposit their coordinates
immediately. This is accepted by most people, and it's quite common for
some authors to delay for a year before letting the rest of the world see
them. To make sure that this happens, they often submit them to PDB, who
hold them in trust for a year before making them public.

(Dave - maybe you'd like to add something to this?)

We therefore have a minor problem for the course, with recent
structures. Sometimes the authors will let people have coordinates if
they send a polite e-mail, but usually only if they know them. We also
can't photocopy diagrams and publich them for the course because that is
a breach of copyright. (It is allowed to make your own drawing if it's
sufficiently different). So I suspect tha we shall limit ourselves to:

- text abstracts (we can do this for any paper, so long as we don't
copy the paper verbatim
- drawing our own schematic diagrams (worth doing if you have a
good tool)
- using those structures with coordinates.

I think it would be a good idea for course members *not* to write directly
to authors of papers (unless they have a totally independent reason for
doing so). I'd value other consultants views on this.

P.

Peter Murray-Rust (pmr1716@ggr.co.uk) Glaxo Research & Development, Greenford,UK
mbglx@seqnet.dl.ac.uk, http://www.dl.ac.uk/CBMT/pmr.html (Thanks to AlanBleasby)