Last modified 17th April '95 © Birkbeck College 1995

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For a detailed description of lipases, we thank Sophie Clarke of York University.

Harpreet Singh has also prepared a page on Triacylglycerol Lipase

Some Carboxylic Esterases

Triacylglycerol hydrolase from Candida rugosa fungus. Three N-acetylglucosamine residues at two sites are included: two N-linked residues at Asn 351 and one N-linked residue at Asn 314. 534 residues.

Triacylglycerol acylhydrolase from Rhizomucor miehei; complexed with diethylphosphate; complex with N-hexylphosphanate ethyl ester (C-alpha atoms only) PIC

Human pancreatic lipase complexed with colipase

Bovine pancreatic phospholipase A2 (phosphatide acyl-hydrolase) with 2 molecules of 2-methyl-2,4-pentanediol. For a detailed description of the active site and a proposal for a reaction mechanism, see Renetseder et al.(1985).

Here is the zymogen , which has seven additional residues at the N-terminus (see REMARK 5 and SEQRES records of the pdb file; N.B. I couldnt seem to find these seven residues though).

Lipases are described by Sophie Clarke of York University in her section on interfacial activation of triacylglyceride lipase.


Enzyme Databases

Lipases in


Here is the index to the Protein Science Kinemages on Lipases.

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J. Walshaw