Last modified 30th Jun '95 © Birkbeck College 1995

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Page 1 (in Ch.7) Page 2 Tertiary Structure; Substrates Page 3 Active Site
Page 4 Diagrams Page 5 Reaction Mechanism Page 7 References

An example of an active site: the serine proteases

Selected Chymotrypsin Crystal Structures


1chg chymotrypsinogen A

2cga chymotrypsinogen A


4cha alpha-chymotrypsin

2gch gamma-chymotrypsin A

Enzyme with cleavage product

8gch gamma-chymotrypsin complex with Gly-Ala-Trp autolytic cleavage product

1gct gamma-chymotrypsin A with autolytic cleavage product

2gct gamma-chymotrypsin A

Enzyme complexed with inhibitor

2cha tosylated alpha-chymotrypsin A Diagram

1cho alpha-chymotrypsin complex with turkey ovomucoid third domain

3gch gamma-chymotrypsin complex with trans-O-hydroxy-alpha-methyl cinnamate

4gch gamma-chymotrypsin complex with P-diethylamino-O-hydroxy-alpha-methyl cinnamate

6gch gamma-chymotrypsin complex with N-acetyl-L-phenylalanyl trifluoromethyl ketone

7gch gamma-chymotrypsin complex with N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone

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J. Walshaw