Postgraduate Certificate:
Protein Crystallography

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bullet MSc structural biology
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Current PX students
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bullet 2009/10 course access
bullet 2008/9 course access

 

Protein Crystallography (PX)

Postgraduate Certificate

PX Syllabus

Section 2 - Diffraction
  • Background
  • Basic Diffraction Theory for Protein Crystallography

Waves and Diffraction Patterns

Complex Numbers

Scattering of X-Rays by Matter
Scattering of X-Rays by Crystals
Bragg's Law
Crystal Planes, Miller Indices and Reflection Indices
The Reciprocal Lattice
The Reciprocal Lattice - Equations (Simplified)

The Reciprocal Lattice - Equations

Bragg's Law in Reciprocal Space (Ewald Construction)
The Temperature Factor and Occupancy Factor
The Structure Factor

  • Basic Fourier Theory for Protein Crystallography

Introduction to Fourier transforms

Theory of the Fourier transform

Exercise 1: Fourier synthesis of an arbitrary function
Exercise 2: Fourier synthesis of the square wave
Exercise 3: Fourier series termination and resolution
Exercise 4: Fourier analysis of cosine and sine functions
Exercise 5: Fourier analysis as the reverse of Fourier synthesis
Exercise 6: Fourier analysis of the box function
Exercise 7: The aliasing effect of the discrete Fourier transform
Exercise 8:  Convolution and autocorrelation