Postgraduate Certificate:
Protein Crystallography

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bullet MSc structural biology
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Current PX students
[Restricted access]

bullet 2009/10 course access
bullet 2008/9 course access

 

Protein Crystallography (PX)

Postgraduate Certificate

PX Syllabus

Section 11 - MAD
  • Introduction
  • Background

Anomalous Scattering
An Overview of MAD Analysis
Anomalous Scattering Factors
Phase Diagram in the Presence of Anomalous Scattering
Phase Determination by MAD - Algebraic Formalism
Phase Determination by MAD - Pseudo-MIR

  • Labelling of Macromolecules for MAD
  • Steps and Strategy

MAD Data Collection

Feasibility Study
Calibration of Wavelength
Data Collection Strategy - Wavelengths
Data Collection Strategy - Point Group Symmetry

MAD Data Processing and Structure Solution

Data Reduction
Local Scaling of Bijvoet Differences followed by Local Scaling of Dispersive Differences
Identification and Refinement of Anomalous Scatterer Positions
Phase Evaluation

Programs