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4. PPII helices in proteins

PPII helices have been found in a large number of proteins using protein crystal structure database analysis, and experimental methods (CD, X-ray crystallography, NMR).

Often found on the surface of globular proteins, being a flexible, hydrophilic structural element, with only few main-chain hydrogen bonds to other parts of the protein, and play an important role in protein-protein interaction (with SH3 domains in intercellular cohesion or enzyme activation), serve (followed by a turn) as a site for proline hydroxilation, linking other structural elements in domain formation.

Here is a short list of a few peptides, proteins or protein families which have this structural element:

Proteins which need PPII helix as substrate:


by Zoltan Szabo , 1997