Protein engineering and its role in solving the phase problem

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Contents

  1. Introduction - protein engineering
  2. Phase problem in macromolecular crystallography
  3. Role of the protein engineering in generation of isomorphous heavy atom derivatives
  4. Selenomethionine substituted protein as a tool for phase determination
  5. Preparation of the selenomethionine-containing proteins for MAD
  6. Use of protein engineering to improve crystals
  7. Conclusion
  8. References

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Department of Crystallography

Maciej Kozak's PPS project

Protein engineering and its role in solving the phase problem