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1) Which of these statements about 4-helix bundles is false ? The four helices in a bundle are almost parallel to each other Myohemerythretin and ferritin contain examples of this fold The ligand binding site is always found at one end of the bundle Four-helix bundles can never be formed from dimers of 2-helix subunits
2) In which of these DNA binding proteins is the DNA binding motif not an alpha helix? the cro repressor the met repressor homeodomain proteins transcription factors which contain the zinc finger motif
3) Which of these all-alpha proteins is also an integral membrane protein ? Bacteriorhodopsin Cytochrome B452 Annexin Phycocyanin
4)How many Greek key motifs are found in one molecule of gamma crystallin? 1 2 4 8
5) Which of these is not a member of the all-beta class of proteins? lysozyme retinol binding protein influenza virus neuraminidase immunoglobulin IgG
6) Which of these statements about the "jelly roll" fold is false? It is an all-beta fold It is found in influenza virus haemagglutinin It can be formed by folding a long antiparallel beta hairpin It always contains exactly eight strands
7) What is the Rossman fold? A doubly wound alpha / beta structure containing a mixed beta sheet A doubly wound alpha / beta structure containing a parallel beta sheet A singly would alpha / beta structure An all-beta fold
8) Which of these proteins contains a left-handed beta-alpha-beta motif ? Flavodoxin Lysozyme Lactate dehydrogenase Triose phosphate isomerase
9) Which of these enzymes does not have the singly-wound alpha/beta topology? Pyruvate kinase Glycolate oxidase Tryptophan synthetase Subtilisin
10) What is the main difference between the alpha / beta and alpha + beta classes of protein structure? In alpha / beta proteins, the helices and strands alternate along the chain In alpha + beta proteins, all the helices are found in one domain and all the strands in another domain In alpha / beta proteins, there are always the same number of helices as strands In alpha + beta proteins, all the helices are found in one chain and all the strands in another chain
11) What are the main ways in which very small protein structures are stabilised ? Always by the formation of disulphide bridges Always by interactions with cofactors or metal ions Usually by disulphide bridge formation or interaction with metal ions By exactly the same mechanisms as all other proteins
12) Which all-beta motif is found in the immunoglobulin domain ? The "jelly roll" fold The Greek key motif The beta helix The beta propeller
Questions by Clare Sansom, Birkbeck College Quiz software by Iddo Freidberg, Hebrew University of Jerusalem