Re: Detecting clusters of amino-acid replacements

Simon Brocklehurst (smb@bioch.ox.ac.uk)
Thu, 8 Jun 1995 11:03:38 +0100 (BST)

> The early [IL-2] structures reported were of limited resolution and accuracy.

I like your choice of words Peter! The original X-ray structure of this
protein was completely wrong! It was withdrawn after it was pointed out
that IL-2 was in fact homologous to other 4-helix bundle cytokines.
The structure was subsequently corrected.
_____________________________________________________________________________
|
| ,_ o Simon M. Brocklehurst,
| / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry,
| \>> | University of Oxford, Oxford, UK.
| \\, E-mail: smb@bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/
|____________________________________________________________________________