I would like to understand the role of the
aspartic acid residue in the catalytic triad
(asp,his,ser) of trypsin/ogen. I understand what the
his and ser are doing during the peptide cleaving, but I
have not been able to figure out what the asp does? Can
someone explain this?
Thanks...
Gail I. Schuman
schuman@bnlstb.bio.bnl.gov
1TGN discussion in the works at:
http://bnlstb.bio.bnl.gov:8000/www_root/webdocs/pps/tryp
sin/trypsinogen.html
PS I also have *still* not worked out the pdb numbering
of this protein...is it done to match chymotrypsin/ogen?
I will try and check on this...since the two have the
same catalytic triad residues and numbering...I thought
this might be the reason for the apparent odd numbering.