The second thing to remember is the rate of this breathing vs. the rates of the
data collection. NMR measures motions on the msec time scale, while
crystalography sees these and motions on the minutes time scale as well since it
takes hours to collect a data set.
Finally, one should not minimize the distance geometry question. NMR structures
are often underdetermined (ie., the number of independent measurements is on the
same order of magnitude as the number of atoms. The more observations you have
the more certain your solution.
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If it's worth doing, it's worth doing to excess!
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Keith D. Wilkinson voice (404) 727-5980
Department of Biochemistry fax (404) 727-3452
Emory University School of Medicine
Atlanta, GA 30322
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