Expertise and technology

Biophysics

Electron microscopy

Immunoinformatics

Microarray analysis

Protein crystallography

Synchrotron CD Spectroscopy

Technology
Biomolecular characterisation using fluorescence spectroscopy, circular dichroism, surface plasmon resonance, analytical ultracentrifugation, transient kinetics and calorimetry.

Applications
Functional studies of macromolecules and their interactions, which may be independent or can complement structural studies or inform lead compound discovery and development.

Technology
Imaging macromolecules by negative stain or cryo-electron microscopy; Image analysis and three-dimensional reconstruction to high resolution.

Applications
Structure determination of large macromolecular assemblies such as viruses, amyloid fibrils, chaperones and pore-forming toxins.

Technology
Developing tools for the prediction of immunogenicity from protein sequence and providing access to them via ImmunologyGrid.

Applications
Prediction of cellular location and MHC binding : vaccine design and prediction of histocompatibility.

Technology Statistical analysis of noisy microarray datasets; development of software tools for the identification of differentially expressed genes Applications Identification of target genes for drug and vaccine development, and of genes involved in regulatory networks

Technology
Automatized crystallization of proteins and peptides. Determination of protein structures to high resolution by X-ray crystallography, as a service or a research collaboration.

Applications
Structural Genomics; Drug target verification; analysis of protein-ligand interactions; inhibitor design and lead verification.

Technology
High throughput circular dichroism assays using high intensity synchrotron radiation enabling the detection of small conformational changes in three dimensional structures

Applications
Drug target validation and ligand identification via “reverse chemical genetics”. Analysis of protein-drug interactions and drug-induced conformational changes;