The Crystallography Department at Birkbeck College and the Virtual School of Natural Sciences (a school of the Globewide Network Academy) are sponsoring a free, multimedia, interactive course on Principles of Protein Structure. The course is freely supported by leading protein structure groups and uses many new technologies for teaching such as classes in BioMOO, use of the Protein Data Bank, CGI forms for self-paced assessment and interactive 3-D viewers for chemical/ MIME types.