OVERVIEW OF PROTEIN SYNTHESIS
Back to Main Index...last updated 14th.August1995
Material available elsewhere includes
Cell Biology Module
at MIT;
A Dictionary of Cell Biology
from Academic Press.
- -Cellular Organisation Mark Dalton is helping with this area
- distinguish prokaryotes and eukaryotes, nucleus, DNA,
chromosomes, membrane(s), cytosol, ER, lumen of ER, Golgi,
organelles, ribosomes, mention viruses(?)
- -DNA and the Central Dogma of Life
- Vineet Gupta
- -Transcription Mary Ann Tuli helped here and more recently
Henry Brzeski
- DNA, Watson-Crick A:T, G:C, unwinding of double helix,
RNA polymerase, U not T, template directed synthesis of ssRNA
->rRNA, tRNA, mRNA, introns/exons in eukaryotes, splicing
(regulation, operons and promoters?)
- -Translation Garry Myers and Ted Crusberg offered help here
- ribosome, attachment to Shine-Dalgarno sequence, genetic code,
start (Met) and stop codons, coding sequence = gene, tRNA-AA,
growth of nascent AA-chain and folding up, mention chaperones
- -Post-translational processing
- distinguish ER-directed vs. cytoplasmic, signal peptide Ted Crusberg?,
peptidase, foldases, glycosylation, myristoylation,
oligomerisation, binding of co-factors, etc
- -Transport Ted Crusberg offered help here
- into ER, to Golgi, lysosomes & export, to and across membrane,
exocytosis, nuclear targeting, pores and channels, binding
proteins, periplasm, circulatory systems in higher organisms
- -Degradation
Keith Wilkinson and Beatrice Gorinsky have contributed here