PROTEIN STRUCTURE GROUP REPORT

Table of Contents

     Multispecific ligand recognition in the oligopeptide-binding protein (OppA) 
     Penicillin Acylase 
     Structural Studies on Cellulases 
     Characterisation and Preliminary Structural Studies of the CysB Protein 
     Structural studies of proteins involved in sporulation 
     Tissue Inhibitors of Metalloproteinases 
     Amylase 
     Methylguanine-DNA Methyltransferase from E. coli 
     Human Papillomavirus Proteins 
     Haemoglobin 
     Structural Studies of Lipases 
     Bacterial Ribonuclease 
     Structure and Ligand Binding Studies of Myoglobin 
     Structural Studies on CD4 and HIV-related proteins 
     Insulin 
     Myristoyl-ACP Specific Thioesterase from Vibrio harveyi 
     Structural Studies on Human Insulin-Like Growth Factor (h-IGF 1) 
     Trp attenuation protein of Bacillus subtilis 
     beta-Eliminating lyases 
     Chimaeric Antibodies 
     Natural selection of enzyme specificity, structural analysis of two isofunction keto-enol isomerases 
     Cloning, overexpression and structural studies of meta-cleavage dioxygenases 
     Solvents in Biologically Relevant Systems 
     Structural and enzymological studies of Ty pe II DNA topoisomerases 
     DNA-Drug Interactions 
     Candida albicans Phosphomannose Iso merase 
     Haemoglobins from an antarctic fish and buffalo 
     Structure of Aspartic Protease from Candida albicans 
     "Crystallisation of an Inhbited Aspart ic Protease from Candida Albicanss 
     Structure of a tetrameric DNA at 1.2Å 
     The high-resolution crystal structure of a parallel-stranded guanine tetraplex 
     Structure of p53 protein 
     Transcription Factor Characterisation 
     Cell Cycle Proteins 
     Small-Molecule Structures 
     CCP4 Program Suite 
     EC Data Validation Project 
     Development of a CIF format for recording the crystallographic 
     Database of protein-ligand complexes 
     Techniques in Structure Based Ligand Design 
     Virtual Reality 
     Analysis of CA Geometry in Proteins 
     Model building into SIR, MIR and MAD electron density maps 
     Holes in proteins 
     Structural alignment in proteins 
     A GUI Controlled Structural Data Managemen t System 
     Modelling G-protein coupled receptors from existing experimental/theoretical data 
     Low Resolution Modelling and Application t o Restraint Satisfaction 
     Dynamics of protein-ligand systems : theor etical studies on L. Casei 
     X-ray Data Collection 
     Computational Resources 
     Molecular Biology 
     Grant Support 1992-93 
     Personnel 
     Publications