In this document I give an overview of protein stability. The contribution each residue makes to, or takes away from, the stability of a protein is small. Thus the stability of a protein is determined by large number of small positive and negative interaction energies. In the sections that follow I discuss some of the factors that give rise to these positive and negative interaction energies. I will also briefly discuss rates of unfolding as they relate to perceived stability (Kinetic Stability), Chemical Degradation of proteins, and the Evolution of stability.
Definition of Stability