Other Factors Affecting Protein Stability

There are a number of other interactions, in addition to those already discussed (The Hydrophobic Effect, Hydrogen Bonds, Conformational Entropy of Unfolding), which make contributions to the stability of proteins. These interactions are few relative to the major factors, but are still have some importance for protein stability. They include:

• Salt Bridges
• Aromatic-Aromatic Interactions
• Metal Binding and
• Disulphide Bonds

Conformational Entropy of Unfolding Salt BridgesBeginning