PPS96 Projects

Cristina Cantale

The Viral Integrases


References


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"Analysis of human immunodeficiency virus type 1 integrase mutants"
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Barsov E.V. et al
"Inhibition of human immu odeficiency virus type 1 integrase by Fab fragment of a specific monoclonal antibody suggest that different multimerization states are required for different enzymatic functions"
J. Virology 70, 4484-4494 (1996)
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Bujacz G. et al.
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"Structural implications of spectroscopic characterization of a putative zinc finger peptide fro HIV-1 integrase"
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Science 249, 1555-1558 (1990)
Bushman F.D. and Craige R.
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J. Virology 68, 4768-4775 (1994)
Cannon P.M. et al
"Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication"
J. Virology 70, 651-657 (1996)
Chalker D.L. and Sandmayer S.B.
"Ty3 integrates within the region of RNA polymerase III transcription initiation"
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"The DNA-binding domain of HIV-1 integrase has an SH£-like fold"
Nature Struc.Biol. 2, 807-810 (1995)
Ellison V. and Brown P.O.
"A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro"
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"An essential interaction between distinct domain of HIV integrase mediates assembly of active multiomer"
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Cell 67, 1211-1221 (1991)
Engelman A. and Craige R.
"Identification of conserved amino acid residues critical for human immonodeficiency virus type 1 integrase function in vitro"
J. Virology 66, 6361-6369 (1992)
Engelman A., Bushman F.D. and Craige R.
"Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex"
The EMBO J. 12, 3269-3275 (1993)
Engelman A., Hickman A.B. and Craige R.
"The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to non specific DNA binding"
J. Virology 68, 5911-5917 (1994)
Engelman A. and Craige R.
"Efficient Magnesium dependent human immonodeficiency virus type 1 integrase activity"
J. Virology 69, 5908-5911 (1995)
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"Functional similarity between retroviruses and the IS3 family of bacterial insertion sequences?"
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J. Virology 58, 970-974 (1986)
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Ann. Rev. Genet. 26, 527-544 (1992)
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"A novel assay for the DNA strand-transfer reaction of HIV-1 inegrase"
Nucl. Acids Res. 22,1121-1122 (1994)
2-Hazuda et al.
"Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase"
J. Biol. Chem. 269, 3999-4004 (1994)
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"Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase"
J. Biol. Chem. 269, 29279-29287 (1994)
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"Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues"
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"Retroviral integrase functions as a multimer and can turn over catalytically"
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"Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes"
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"The Avian Retroviral IN Protein is both necessary and sufficient for integrative recombination in vitro"
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"The avian retroviral Integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration"
J. Virology 63, 5319-5327 (1989)
Katzman M. end Sudol M.
"Mapping domains of retroviral integrase Responsable for viral DNA Specificity and target site selection by analysis of chimeras between Human Immunodeficiency virus type 1 and visna virus integrases"
J. Virology 69, 5687-5696 (1995)
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Mol. Cell. Biol. 12, 2331-2338 (1992)
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"Activities and substrate specificity of the evolutionary conserved central domain of retroviral integrase"
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"Protection of retroviral DNA from autointegration: involvment of a cellular factor"
Proc. Natl. Acad. Sci. USA 91, 9823-9827 (1994)
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"Solution structure of DNA binding domain of HIV-1 integgrase"
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Mol. Cell. Biol. 12,4015-4025 (1992)
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Nielsen B.M. et al.
"Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping an differential effects on integrase activities in vitro"
J. Virology 70, 1580-1587 (1996)
Pahl A. and Flugel R.M.
"Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complemantation analysis and by swapping tha zinc finger domain of HIV-1"
J. Biol. Chem. 270, 2957-2966 (1995)
Polard P. and Chandler M.
"Bacterial transposases and retroviral integrases"
Mol. Microbiol. 15, 13-23 (1995)
Pryciak P.M. and Varmus H.E.
Nucleosomes, DNA-binding proteins and DNA sequence modulate retroviral integration target site selection"
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Reicin A.S. et al.
"Sequences in thehuman immunodeficiency virus type 1 U3 region required for in vivo and in vitro integration"
J. Virology 69, 5904-5907 (1995)
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"Inhibitors of HIV-1 replication that inhibit HIV integrase"
Proc. Natl. Acad. Sci. USA 93, 6326-6331 (1996)
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"Analysis of mutations in the integration function of Moloney Murine Leukemia virus: effects on DNA binding and cutting"
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Sharp P.M. and Li W.
"Understanding the origins of AIDS viruses"
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Shin C.G. et al.
"Genetic analysis of the human immunodeficiency virus type 1 integrase protein"
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Yu S.F. et al.
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"DNA binding properties of the integrase proteins oh human immunodeficiency viruses types 1 and 2"
Nucl. Acids Res. 19, 3821-3827 (1991)
van Gent D.C. et al.
"Complementation between HIV integrase proteins mutated in different domains"
The EMBO J. 12, 3261-3267 (1993)
Vincent K.A. et al.
"Characterization of Human Immunodeficiency virus type 1 Integrase expressed in E.coli and analysis of variants with amino-terminal mutations"
J. Virology 67, 425-437 (1993)
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"Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein"
Nucl. Acids Res. 19, 6691-6698 (1991)
2-Vink C. et al.
"Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficien cleavage"
J. Virology 65, 4636-4644 (1991)
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"Identification of the catalytic and DNA binding region of the human immunodeficiency virus type 1 integrase protein requires"
Nucl. Ac. Res. 21, 1419-1425 (1993)
Vink C. et al.
"Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA"
Nucl. Ac. Res. 22, 4103-4110 (1994)
Wolfe A.L. et al.,
"The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrases as a catalytically active complex on immobilized long terminal repeat substrates"
J. Virology 70, 1424-1432 (1996)

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Last updated 25th Oct '96