PPS96 Projects

Cristina Cantale

The Viral Integrases


Ansari-Lare M.A. et al.
"Analysis of human immunodeficiency virus type 1 integrase mutants"
Virology 211, 332-335 (1995)
Barsov E.V. et al
"Inhibition of human immu odeficiency virus type 1 integrase by Fab fragment of a specific monoclonal antibody suggest that different multimerization states are required for different enzymatic functions"
J. Virology 70, 4484-4494 (1996)
Bowerman B. et al.
"A nucleoprotein complex mediates the integration of retroviral DNA"
Genes & Dev. 3, 469-478 (1989)
Brown P.O. et al.
"Correct integration of retroviral DNA in vitro"
Cell 49, 347-356 (1987)
Brown P.O. et al.
"Retroviral integration: structure of the initial covalent product and its precursor and a role for the viral IN protein"
Proc. Natl. Acad. Sci. USA 86, 2525-2529 (1989)
Bujacz G. et al.
"High resolution structure of the catalytic domain of avian sarcoma virus integrase"
J. Mol. Biol. 253, 333-346 (1995)
Bujacz G. et al.
"The catalytic domain of avian sarcoma virus integrase: conformation of the active site residues in the presence of divalent cations"
Structure 4, 89 (1996)
Burke C.J. et al.
"Structural implications of spectroscopic characterization of a putative zinc finger peptide fro HIV-1 integrase"
J. Biol. Chem. 267, 9639-9644 (1992)
Bushman F.D. , Fujiwara T. and Craige R.
"Retroviral DNA integration directed by HIV Integration Protein in vitro"
Science 249, 1555-1558 (1990)
Bushman F.D. and Craige R.
"Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA"
Proc. Natl. Acad. Sci. USA 88, 1339-1343 (1991)
Bushman F.D. et al.
"Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding"
Proc Nat. Acad. Sci. USA 90, 3428-3432 (1993)
Cannon P.M. et al
"Human immunodeficiency virus type 1 integrase:effect on viral replication of mutations at higly conserved residues"
J. Virology 68, 4768-4775 (1994)
Cannon P.M. et al
"Conserved sequences in the carboxyl terminus of integrase that are essential for human immunodeficiency virus type 1 replication"
J. Virology 70, 651-657 (1996)
Chalker D.L. and Sandmayer S.B.
"Ty3 integrates within the region of RNA polymerase III transcription initiation"
Genes Dev. 6, 117-128
Chow S.A. et al.
"Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus"
Science 255,723-726 (1992)
Chiu I. et al.
"Major pol Gene Progenoitors in the evolution of Oncoviruses"
Science 223, 364-370 (1984)
Doak T.G. et al.
"A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a commom "D35E" motif"
Proc. Natl. Acad. Sci. USA 91, 942-946
Dyda F. et al
"Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases"
Science 266, 1981-1986 (1994)
Eijkelenboom A.P.A.M. et al.
"The DNA-binding domain of HIV-1 integrase has an SH£-like fold"
Nature Struc.Biol. 2, 807-810 (1995)
Ellison V. and Brown P.O.
"A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro"
Proc. Natl. Acad. Sci. USA 91, 7613-7320 (1994)
Ellison V. et al.
"An essential interaction between distinct domain of HIV integrase mediates assembly of active multiomer"
J. Biol.Chem. 270, 3320-3326 (1995)
Engelman A., Mizuuchi K. and Craige R.
"HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer"
Cell 67, 1211-1221 (1991)
Engelman A. and Craige R.
"Identification of conserved amino acid residues critical for human immonodeficiency virus type 1 integrase function in vitro"
J. Virology 66, 6361-6369 (1992)
Engelman A., Bushman F.D. and Craige R.
"Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex"
The EMBO J. 12, 3269-3275 (1993)
Engelman A., Hickman A.B. and Craige R.
"The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to non specific DNA binding"
J. Virology 68, 5911-5917 (1994)
Engelman A. and Craige R.
"Efficient Magnesium dependent human immonodeficiency virus type 1 integrase activity"
J. Virology 69, 5908-5911 (1995)
Fayet O. et al.
"Functional similarity between retroviruses and the IS3 family of bacterial insertion sequences?"
Mol.Microbiol 4, 1771-1777 (1990)
Fesen M.R. et al
"Inhibitors of human immunodeficiency virus integrase"
Proc. Natl. Acad. Sci. USA 90, 2399-2403 (1993)
Fujiwara T. and Mizuuchi K.
"Retroviral DNA integration: structure of an integration intermediate"
Cell 54, 497-504 (1988)
Grandgennet D.P. et al.
"Nuclease mechanism of the avian retrovirus pp32 endonuclease"
J. Virology 58, 970-974 (1986)
Goff S.P.
" Genetics of retroviral integration"
Ann. Rev. Genet. 26, 527-544 (1992)
1-Hazuda et al.
"A novel assay for the DNA strand-transfer reaction of HIV-1 inegrase"
Nucl. Acids Res. 22,1121-1122 (1994)
2-Hazuda et al.
"Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase"
J. Biol. Chem. 269, 3999-4004 (1994)
Hickman A.B. et al.
"Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase"
J. Biol. Chem. 269, 29279-29287 (1994)
Jenkins T.M. et al.
"Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues"
Proc. Nat. Acad. Sci. USA 92, 6057-6061 (1995)
Jenkins T.M. et al.
"A soluble active mutant of HIV-1 integrase"
J. Biol. Chem. 271, 7712-7718 (1996)
Johnson M.S. et al
"Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes"
Proc. Nat. Acad. Sci: USA 83, 7648-7652 (1986)
Jones K.S. et al.
"Retroviral integrase functions as a multimer and can turn over catalytically"
J. Biol. Chem. 267, 16037-16040 (1992)
Kassavetis et al.
"Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes"
Mol. Cell. Biol. 9, 2551-2566 (1989)
Katz R.A. et al.
"The Avian Retroviral IN Protein is both necessary and sufficient for integrative recombination in vitro"
Cell 63, 87-95 (1990)
Katzman M. et al.
"The avian retroviral Integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration"
J. Virology 63, 5319-5327 (1989)
Katzman M. end Sudol M.
"Mapping domains of retroviral integrase Responsable for viral DNA Specificity and target site selection by analysis of chimeras between Human Immunodeficiency virus type 1 and visna virus integrases"
J. Virology 69, 5687-5696 (1995)
Khan E. et al.
"Retroviral integrase domain: DNA binding and the recognitin of LTR sequences"
Nucl. Acids Res. 19, 851-860 (1990)
Kulkosky J. et al
"Residual critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases"
Mol. Cell. Biol. 12, 2331-2338 (1992)
Kulkosky J. et al
"Activities and substrate specificity of the evolutionary conserved central domain of retroviral integrase"
Virology, 206, 448-456 (1995)
Lee M.S. an Craige R.
"Protection of retroviral DNA from autointegration: involvment of a cellular factor"
Proc. Natl. Acad. Sci. USA 91, 9823-9827 (1994)
Lin T.H. and Grandgenett D.P.
"Retrovirus integrase: identification of a potential leucine zipper motif"
Prot. Engin. 4, 435-441 (1991)
Lin T.H. et al.
"Secondary structural analysis of retrovirus integrase: characterization by circular dichroism and empirical prediction methods"
Proteins 5, 156-165 (1989)
Lodi P.J. et al.
"Solution structure of DNA binding domain of HIV-1 integgrase"
Biochemistry 34, 9826-9833 (1995)
Lewin Benjamin
J. Wiley & Sons
McClure M.A. et al.
"Sequences comparison of retroviral proteins: Relative rates of change and general phylogeny"
Pro. Natl. Acad. Sci. USA 85, 2469-2473 (1988)
Morse R.H. et al
"A transcriptionally active tRNA gene interferes with nucleosome positioning in vivo"
Mol. Cell. Biol. 12,4015-4025 (1992)
MullerH.P. and Varmus H.E.
"DNA bending creates favored sites for retroviral integration: an explanation for preferrea insertion sites in nucleosomes"
EMBO J. 13, 4704-4714 (1994)
Nielsen B.M. et al.
"Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping an differential effects on integrase activities in vitro"
J. Virology 70, 1580-1587 (1996)
Pahl A. and Flugel R.M.
"Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complemantation analysis and by swapping tha zinc finger domain of HIV-1"
J. Biol. Chem. 270, 2957-2966 (1995)
Polard P. and Chandler M.
"Bacterial transposases and retroviral integrases"
Mol. Microbiol. 15, 13-23 (1995)
Pryciak P.M. and Varmus H.E.
Nucleosomes, DNA-binding proteins and DNA sequence modulate retroviral integration target site selection"
Cell 69, 769-780 (1992)
Pruss D. et al.
"The infuence of DNA and Nucleosome Structure on integration events directed by HIV integrase"
J. Biol. Chem. 40, 25031-25041 (1994)
Querat G. et al.
"Nucleotide sequence analysis of SA-OMVV, a Visna related ovine lentivirus: phylogenetic History of lentiviruses"
Virology, 175, 434-447 (1990)
Reicin A.S. et al.
"Sequences in thehuman immunodeficiency virus type 1 U3 region required for in vivo and in vitro integration"
J. Virology 69, 5904-5907 (1995)
Robinson W.E. et al.
"Inhibitors of HIV-1 replication that inhibit HIV integrase"
Proc. Natl. Acad. Sci. USA 93, 6326-6331 (1996)
Roth M.J. et al.
"Analysis of mutations in the integration function of Moloney Murine Leukemia virus: effects on DNA binding and cutting"
J Virlogy 64, 4709-4717 (1990)
Sagata N. et al.
"Complete nucleotide sequence of the genoma of bovine leukemia virus: Its evolutionary relationship to other retroviruses"
Proc. Natl. Acad. Sci. USA 82, 677-681 (1985)
Sharp P.M. and Li W.
"Understanding the origins of AIDS viruses"
Nature 336, 315 (1988)
Shin C.G. et al.
"Genetic analysis of the human immunodeficiency virus type 1 integrase protein"
J. Virology 68, 1633-42 (1994)
Sonigo P. et al.
"Nucleotide Sequence of the Visna Lentivirus: Relationship to the AIDS Virus"
Cell 42, 370-382
Stephens R.M. et al.
"Equine infectious anemia virus gag and pol genes:relatedness to Visna and AIDS virus"
Science 231,589-594
Yu S.F. et al.
"Human Foamy Virus Replication: A Pathway Distinct from That of Retroviruses and Hepadnaviruses"
Science 271, 1579-1582 (1996)
van Gent D.C. et al.
"DNA binding properties of the integrase proteins oh human immunodeficiency viruses types 1 and 2"
Nucl. Acids Res. 19, 3821-3827 (1991)
van Gent D.C. et al.
"Complementation between HIV integrase proteins mutated in different domains"
The EMBO J. 12, 3261-3267 (1993)
Vincent K.A. et al.
"Characterization of Human Immunodeficiency virus type 1 Integrase expressed in E.coli and analysis of variants with amino-terminal mutations"
J. Virology 67, 425-437 (1993)
1-Vink C. et al.
"Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein"
Nucl. Acids Res. 19, 6691-6698 (1991)
2-Vink C. et al.
"Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficien cleavage"
J. Virology 65, 4636-4644 (1991)
Vink C. et al.
"Identification of the catalytic and DNA binding region of the human immunodeficiency virus type 1 integrase protein requires"
Nucl. Ac. Res. 21, 1419-1425 (1993)
Vink C. et al.
"Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA"
Nucl. Ac. Res. 22, 4103-4110 (1994)
Wolfe A.L. et al.,
"The role of manganese in promoting multimerization and assembly of human immunodeficiency virus type 1 integrases as a catalytically active complex on immobilized long terminal repeat substrates"
J. Virology 70, 1424-1432 (1996)

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Last updated 25th Oct '96