PPS96 Projects

Cristina Cantale

ABSTRACT

We summarize here the current understanding about Integrase Proteins. Integrase proteins are a family of endonuclease involved in the retroviral infection.
The genome structure and the life cycle of retroviruses are described.
Integrase proteins are described with respect to the following issues: the integration mechanism, the sequence, the three dimensional structure and the therapeutical implications.
Analogies between integrases and other proteins are reported with emphasis about the conserved regions.
Phylogenetic trees are also reported.

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Last updated 25th Oct '96