John tells me that there are serine proteases with completely different
folds but with very similar active site geometry but that this is
considered to have occured due to convergent rather than divergent
evolution.
Regards,
Will
____________________________________________________________
Will Pitt Tel: 44-171-5806851
Crystallography Department, Fax: 44-171-5806803
Birkbeck College, w.pitt@mail.cryst.bbk.ac.uk
Malet Street, http://www.cryst.bbk.ac.uk/~ubcg08l/
London
WC1E 7HX
U.K.
On Fri, 24 May 1996, Sophia Kossida wrote:
> Dear Will,
>
> Two genes are said to be paralogous if they are derived from a duplication
> event, but orthologous if they are derived from a speciation event. This is
> how the above terms are used, at least, in an evolutionary context.
>
> Cheers
> Sophia
>
> =====================================================
> Sophia Kossida
> Merton College
> Oxford OX1 4JD
> England
> e-mail: sophia.kossida@merton.oxford.ac.uk
> tel : (44) (0) 1865 271263
> fax : (44) (0) 1865 310447
> URL : http://users.ox.ac.uk/~mert0223
> =====================================================
>
>
>