Re: The meaning of PCA

t.walsh@qut.edu.au
Wed, 20 Mar 1996 07:55:41 -1000

>Dear all,
>
>PCA stands for L-2-Pyrrolidone-5- Carboxylix acid,
>
>which is another way of saying
>
>L-Pyroglutamic Acid (Is the light appearing?)
>

Thanks Jim. I've only ever referred to it as pyroglutamate, and haven't
come across a pdb with one in it before.

>
>which is a post-translational modification that
>
>can occur when proteins are expressed in recombinant
>
>DNA systems e.g. E.coli, and cause serious grief when

Does the native molecule (non-recombinant) have pyroglu?

>Today I would use "PYR" instead of "PCA" but
>
>Brookhaven continue to use the latter.
>

Can we add this information to the glossary?

>
>Question: What has happened to the
>
>two carbon atoms (gamma and delta)
>
>required to form the ring?
>
>Jim Pitts.

Pass. Too mobile to be defined seems unlikely in view of the relatively
rigid structure.

Terry

Dr Terry Walsh
School of Life Science
Queensland University of Technology GP
GPO Box 2434 Brisbane 4001 Phone +61 7 3864 2347
AUSTRALIA Fax +61 7 3864 1534