Re: Hydrophobicity (Summary so far...)

Simon Brocklehurst (
Thu, 1 Feb 1996 15:16:14 +0000 (GMT)

Nice answers to the questions on residue hydrophobicity that I
posed. I thought I might just summarize things so far...


For the most hydrophobic residue, so far we have:

I, L, F

For the most hydrophilic/least hydrophobic residue, so far we have:

N, D (with a question about whether the charged or
uncharged form is the more hydrophobic)

I won't give an answer to my third question yet - I'm hoping that
one of the people who've e-mailed me privately about this will
post that. I don't want to spoil the surprise, but I will say it's
neither N nor D...

I won't make any comments on the choices my self at the moment.
Some good questions have been raised that I don't think have been
answered yet... these include:

Are charged residues more or less hydrophilic than uncharged residues?

How do hydrophobicities of aliphatic and aromatic compounds compare?

Keep going everyone!

-- Simon
| ,_ o Simon M. Brocklehurst,
| / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry,
| \>> | University of Oxford, Oxford, UK.
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