Re: Hydrophobicity of residues

Peter Slickers (
Thu, 1 Feb 1996 14:58:25 +0100 (MET)

Dear Jens,

you can measure hydrophobicity by the distribution coefficient
of a given molecule between a polar and a nonpolar phase, let's say
water and hexan.

So there are two aspects of hydrophobicity: first, there are
favorable interactions between the molecule and other nonpolar
molecules (which can be a nonpolar solvent or neighbouring
hydrophobic side chains in a protein), and second, there are
unfavorable interactions with other polar molecules like water.
The water will form an ordered surface around an hydrophobic
AA side chain, which is highly unfavorable from the entropy.


Peter Slickers                        
Institut fuer Molekulare Biotechnologie
Beutenbergstrasse 11, Jena                      Tel.: +49-3641-65-6202
Postfach 10 08 13, D-07708 Jena, Germany        Fax:  +49-3641-65-6210