Re: Science Aug. 2nd

Hao Li (
Wed, 28 Aug 96 14:58:03 -0400

Dr. Barnard raised an interesting point. It is conceivable that
kinetic accessibility could put an additional constraint on
"good" structures. It is natural to
ask the question "are there highly designable
structures which are not accessible (in a reasonable time) in a folding
process?" It seems that high designability implicitly
implies foldability, at least in our simple model.
The correlation between the designability and
energy gap we found suggests that highly designable structures
are also easy to fold into. Recently, we have done some Monte-Carlo
folding simulations and found that
highly designable structures indeed fold faster than
ordinary structures. Whether this is true for larger structures
remains to be seen.

--Hao Li

Hao Li, NEC Research Institute, Inc. 4 Independence Way, Princeton, NJ 08540
Voice (609)951-2888 Fax (609)951-2496 email: