I've been following the interesting discussion that seems (very naturaly) to=
=20
have concentrated on the stability against mutations. Being a physical=20
chemist, the aspect that puzzled me was the coincidence between stability to=
=20
mutations(whatever that means exactly) and thermodinamic stability.
The former seems to follow quite nicely from the starting model of lattice=
=20
proteins composed of two aminoacids. Wether the conclusions are applicable=
=20
to real proteins, that's what we've been discussing.
The connection to thermodinamic stability is difficult to rationalize. Is it=
=20
just because of the entropy term ?
In that case, the result is a no result.
Or is it an artifact of the arbitrary choice of Epp, Ehh and Ehp ?
Luis
=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=
=3D=3D=3D=3D=3D=3D=3D=3D=3D
- \ Luis Pedro Candeias
/_ _\ Gray Laboratory Cancer Research Trust
O / O ) PO Box 100 Mount Vernon Hospital
/_ =A6 Northwood Middlesex HA6 2JR, UK
___ Tel.: +44-1923-82 86 11
Fax.: +44-1923-83 52 10
<>O<> e-mail: candeias@graylab.ac.uk
/ \ www: http://www.graylab.ac.uk/usr/candeias/