Re: Science, Aug 2nd

Luis (
Tue, 20 Aug 1996 18:56:50 +0100

Hi, all !

I've been following the interesting discussion that seems (very naturaly) to=
have concentrated on the stability against mutations. Being a physical=20
chemist, the aspect that puzzled me was the coincidence between stability to=
mutations(whatever that means exactly) and thermodinamic stability.

The former seems to follow quite nicely from the starting model of lattice=
proteins composed of two aminoacids. Wether the conclusions are applicable=
to real proteins, that's what we've been discussing.

The connection to thermodinamic stability is difficult to rationalize. Is it=
just because of the entropy term ?
In that case, the result is a no result.
Or is it an artifact of the arbitrary choice of Epp, Ehh and Ehp ?

- \ Luis Pedro Candeias
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