This reminds me of the old question:
"Why are proteins so large?"
My long-time suspicion was to "provide a buffer" against the cumulative effect
of mutations and to "suppress unwanted side-reactions" (or whatever 'reaction'
may mean in the context of non-enzymes).
The question has never been adequately answered, as far as I know.
I'll have to read the paper in it's entirety myself, before I comment on it
Keep the discussion going...
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