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4.0 Identification of Secondary Structure

4.3 Prediction of Secondary Structure

Sometimes it is of interest to know something about the secondary structure of a protein even though it is not possible to determine experimentally the secondary structure. Ever since the first three-dimensional structure of a protein was determined, people have tried to predict structural information from the amino acid sequence. Large quantities of independent experimental evidence has confirmed that the conformation of a globular protein is determined by the amino acid sequence (see Anfinson, 1973; and for a recent review see Creighton, 1992). So essential is the understanding of the relationship between the amino acid sequence and the three-dimensional conformation that it has been called the second-half of the genetic code. Since most residues (>90%) are in one form of secondary structure or another this would appear to be a good place to start. Several secondary structure prediction methods are discussed in the sections below.

4.3.1 - homology
4.3.2 - statistical
4.3.3 - stereochemical

No Title - 31 MAY 96
written by Kurt D. Berndt

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